Nanoprecipitation preparation of low temperature-sensitive magnetoliposomes

Calvin C L Cheung, Ilaria Monaco, Nina Kostevšek, Wafa T Al-Jamal

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
139 Downloads (Pure)


Lysolipid-containing thermosensitive liposomes (LTSL) have gained attention for triggered release of chemotherapeutics. Superparamagnetic iron oxide nanoparticles (SPION) offers multimodal imaging and hyperthermia therapy opportunities as a promising theranostic agent. Combining LTSL with SPION may further enhance their performance and functionality of LTSL. However, a major challenge in clinical translation of nanomedicine is the poor scalability and complexity of their preparation process. Exploiting the nature of self-assembly, nanoprecipitation is a simple and scalable technique for preparing liposomes. Herein, we developed a novel SPION-incorporated lysolipid-containing thermosensitive liposome (mLTSL10) formulation using nanoprecipitation. The formulation and processing parameters were carefully designed to ensure high reproducibility and stability of mLTSL10. The effect of solvent, aqueous-to-organic volume ratio, SPION concentration on the mLTSL10 size and dispersity was investigated. mLTSL10 were successfully prepared with a small size (∼100 nm), phase transition temperature at around 42 °C, and high doxorubicin encapsulation efficiency. Indifferent from blank LTSL, we demonstrated that mLTSL10 combining the functionality of both LTSL and SPION can be successfully prepared using a scalable nanoprecipitation approach.

Original languageEnglish
Pages (from-to)111453
Early online date06 Nov 2020
Publication statusEarly online date - 06 Nov 2020

Bibliographical note

Copyright © 2020 Elsevier B.V. All rights reserved.


Dive into the research topics of 'Nanoprecipitation preparation of low temperature-sensitive magnetoliposomes'. Together they form a unique fingerprint.

Cite this