Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications

Zhijun Guo, Nan Jiang, Jessica Moore, Colin McCoy, Monika Ziminska, Cormac Rafferty, Gianluca Sarri, Andrew Hamilton, Yubao Li, Li Zhang, Songsong Zhu, Dan Sun

Research output: Contribution to journalArticle

2 Citations (Scopus)
13 Downloads (Pure)

Abstract

Through a nature-inspired layer-by-layer assembly process, we developed a unique multifunctional tissue scaffold that consists of porous polyurethane substrate and nanoscale chitosan/graphene oxide hybrid coating. Alternative layers of drug-laden chitosan and graphene oxide nanosheets were held together through strong electrostatic interaction, giving rise to a robust multilayer architecture with control over structural element orientation and chemical composition at nanoscale. Combined pH-controlled co-delivery of multiple therapeutic agents and photothermal therapy has been achieved by our scaffold system. The new platform technology can be generalized to produce other tissue scaffold systems and may enable potential multimodal therapeutic applications such as bone cancer managements.
Original languageEnglish
JournalACS Applied Materials and Interfaces
DOIs
Publication statusPublished - 19 Jun 2019

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