Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications

Zhijun Guo; Nan Jiang; Jessica Moore; Colin McCoy; Monika Ziminska; Cormac Rafferty; Gianluca Sarri; Andrew Hamilton; Yubao Li; Li Zhang; Songsong Zhu; Dan Sun

doi:10.1021/acsami.9b04278

Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications

Zhijun Guo, Nan Jiang, Jessica Moore, Colin McCoy, Monika Ziminska, Cormac Rafferty, Gianluca Sarri, Andrew Hamilton, Yubao Li, Li Zhang, Songsong Zhu, Dan Sun

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

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Abstract

Through a nature-inspired layer-by-layer assembly process, we developed a unique multifunctional tissue scaffold that consists of porous polyurethane substrate and nanoscale chitosan/graphene oxide hybrid coating. Alternative layers of drug-laden chitosan and graphene oxide nanosheets were held together through strong electrostatic interaction, giving rise to a robust multilayer architecture with control over structural element orientation and chemical composition at nanoscale. Combined pH-controlled co-delivery of multiple therapeutic agents and photothermal therapy has been achieved by our scaffold system. The new platform technology can be generalized to produce other tissue scaffold systems and may enable potential multimodal therapeutic applications such as bone cancer managements.

Original language	English
Pages (from-to)	27269
Journal	ACS Applied Materials and Interfaces
Volume	11
Issue number	30
DOIs	https://doi.org/10.1021/acsami.9b04278
Publication status	Published - 19 Jun 2019

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10.1021/acsami.9b04278Licence: Unspecified

Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications
Copyright 2019 ACS. This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 1.77 MBLicence: Unspecified

Dataset for Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications
Guo, Z. (Creator), Jiang, N. (Creator), Moore, J. (Creator), McCoy, C. (Creator), Ziminska, M. (Creator), Rafferty, C. (Creator), Sarri, G. (Creator), Hamilton, A. (Creator), Li, Y. (Creator), Zhang, L. (Creator), Zhu, S. (Creator) & Sun, D. (Creator), Queen's University Belfast, 2019
DOI: 10.17034/3f1b3b75-cdc7-48f0-b419-92834bf52227
Dataset

File

Development and characterisation of photosensitiser-incorporated polymeric microparticles
Moore, J. (Author), Irwin, N. (Supervisor) & McCoy, C. (Supervisor), Dec 2020
Student thesis: Doctoral Thesis › Doctor of Philosophy
Laser-driven synthesis of nanoparticles for therapeutic applications
Rafferty, C. (Author), Sarri, G. (Supervisor), Riley, D. (Supervisor) & Chan, C. W. (Supervisor), Dec 2022
Student thesis: Doctoral Thesis › Doctor of Philosophy

File

Colin McCoy
- C.McCoyqub.acuk
- School of Pharmacy - Dean of the Graduate School
- Material and Advanced Technologies for Healthcare
Person: Academic
Dan Sun
- d.sunqub.acuk
- School of Mechanical and Aerospace Engineering - Senior Lecturer
- Material and Advanced Technologies for Healthcare
Person: Academic

Cite this

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title = "Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications",

abstract = "Through a nature-inspired layer-by-layer assembly process, we developed a unique multifunctional tissue scaffold that consists of porous polyurethane substrate and nanoscale chitosan/graphene oxide hybrid coating. Alternative layers of drug-laden chitosan and graphene oxide nanosheets were held together through strong electrostatic interaction, giving rise to a robust multilayer architecture with control over structural element orientation and chemical composition at nanoscale. Combined pH-controlled co-delivery of multiple therapeutic agents and photothermal therapy has been achieved by our scaffold system. The new platform technology can be generalized to produce other tissue scaffold systems and may enable potential multimodal therapeutic applications such as bone cancer managements.",

author = "Zhijun Guo and Nan Jiang and Jessica Moore and Colin McCoy and Monika Ziminska and Cormac Rafferty and Gianluca Sarri and Andrew Hamilton and Yubao Li and Li Zhang and Songsong Zhu and Dan Sun",

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AU - Jiang, Nan

AU - Moore, Jessica

AU - McCoy, Colin

AU - Ziminska, Monika

AU - Rafferty, Cormac

AU - Sarri, Gianluca

AU - Hamilton, Andrew

AU - Li, Yubao

AU - Zhang, Li

AU - Zhu, Songsong

AU - Sun, Dan

PY - 2019/6/19

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Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications

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Datasets

Dataset for Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications

Student theses

Development and characterisation of photosensitiser-­incorporated polymeric microparticles

Laser-driven synthesis of nanoparticles for therapeutic applications

Profiles

Colin McCoy

Dan Sun

Cite this

Development and characterisation of photosensitiser-incorporated polymeric microparticles