Nanovaccines: Nanocarriers for antigen delivery

Jose Vicente Gonzalez-Aramundiz, Ana Sara Cordeiro, Nœmi Csaba, Maria De La Fuente, María José Alonso*

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Vaccination has become one of the most important health interventions of our times, revolutionizing health care, and improving the quality of life and life expectancy of millions all over the world. In spite of this, vaccine research remains a vast field for innovation and improvement. Indeed, the shift towards the use of sub-unit antigens, much safer but less immunogenic, and the recognized need to facilitate the access to vaccines in the global framework is currently stimulating the search for safe and efficient adjuvants and delivery technologies. Within this context, nanocarriers have gained particular attention over the last years and appear as one of the most promising strategies for antigen delivery. A number of biomaterials and technologies can be used to design nanovaccines that fulfill the requirements of new vaccination approaches, such as single-dose and transmucosal immunization, critical for achieving a widespread coverage while reducing the overall costs in relation to traditional forms of vaccination. Here we present an overview of the current state of nanocarriers for antigen delivery, developed with the perspective of contributing to the global vaccination goal.

Original languageEnglish
Pages (from-to)249-261
Number of pages13
JournalBiologie Aujourd'hui
Volume206
Issue number4
DOIs
Publication statusPublished - 01 Dec 2012
Externally publishedYes

Keywords

  • Mucosal immunization
  • Nanoparticles
  • Single-dose vaccination
  • Sub-unit antigens
  • Vaccination

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Gonzalez-Aramundiz, J. V., Cordeiro, A. S., Csaba, N., De La Fuente, M., & Alonso, M. J. (2012). Nanovaccines: Nanocarriers for antigen delivery. Biologie Aujourd'hui, 206(4), 249-261. https://doi.org/10.1051/jbio/2012027