Narrow-band ultraviolet B treatment boosts serum 25-hydroxyvitamin D in patients with psoriasis on oral vitamin D supplementation

Meri J. Ala-Houhala, Toni Karppinen, Katja Vähävihu, Hannu Kautiainen, Yvonne Dombrowski, Erna Snellman, Jürgen Schauber, Timo Reunala

Research output: Contribution to journalArticle

17 Citations (Scopus)
290 Downloads (Pure)

Abstract

A course of treatment with narrow-band ultraviolet B (NB-UVB) improves psoriasis and increases serum 25-hydroxyvitamin D (25(OH)D). In this study 12 patients with psoriasis who were supplemented with oral cholecalciferol, 20 µg daily, were given a course of NB-UVB and their response measured. At baseline, serum 25(OH)D was 74.14 ± 22.9 nmol/l. At the 9th exposure to NB-UVB 25(OH)D had increased by 13.2 nmol/l (95% confidence interval (95% CI) 7.2–18.4) and at the 18th exposure by 49.4 nmol/l (95% CI 35.9–64.6) above baseline. Psoriasis Area Severity Index score improved from 8.7 ± 3.5 to 4.5 ± 2.0 (p < 0.001). At baseline, psoriasis lesions showed low vitamin D metabolizing enzyme (CYP27A1, CYP27B1) and high human β-defensin-2 mRNA expression levels compared with those of the healthy subjects. In conclusion, NB-UVB treatment significantly increases serum 25(OH)D in patients with psoriasis who are taking oral vitamin D supplementation, and the concentrations remain far from the toxicity level. Healing psoriasis lesions show similar mRNA expression of vitamin D metabolizing enzymes, but higher antimicrobial peptide levels than NB-UVB-treated skin in healthy subjects.
Original languageEnglish
Pages (from-to)146-151
Number of pages6
JournalActa Dermato-Venereologica
Volume94
Issue number2
Early online date27 Aug 2013
DOIs
Publication statusPublished - Mar 2014

Keywords

  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
  • Administration, Oral
  • Adult
  • Biopsy
  • Cholecalciferol
  • Cholestanetriol 26-Monooxygenase
  • Female
  • Humans
  • Male
  • Middle Aged
  • Psoriasis
  • RNA, Messenger
  • Real-Time Polymerase Chain Reaction
  • Skin
  • Ultraviolet Therapy
  • Vitamin D
  • Vitamin D Deficiency
  • Vitamins
  • beta-Defensins

Fingerprint Dive into the research topics of 'Narrow-band ultraviolet B treatment boosts serum 25-hydroxyvitamin D in patients with psoriasis on oral vitamin D supplementation'. Together they form a unique fingerprint.

  • Cite this