NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

J Tyson McDonald, Robert Stainforth, Jack Miller, Thomas Cahill, Willian A da Silveira, Komal S Rathi, Gary Hardiman, Deanne Taylor, Sylvain V Costes, Vinita Chauhan, Robert Meller, Afshin Beheshti

Research output: Contribution to journalArticle

26 Downloads (Pure)

Abstract

Background: Ionizing radiation from galactic cosmic rays (GCR) is one of the major risk factors that will impact the health of astronauts on extended missions outside the protective effects of the Earth's magnetic field. The NASA GeneLab project has detailed information on radiation exposure using animal models with curated dosimetry information for spaceflight experiments. Methods: We analyzed multiple GeneLab omics datasets associated with both ground-based and spaceflight radiation studies that included in vivo and in vitro approaches. A range of ions from protons to iron particles with doses from 0.1 to 1.0 Gy for ground studies, as well as samples flown in low Earth orbit (LEO) with total doses of 1.0 mGy to 30 mGy, were utilized. Results: From this analysis, we were able to identify distinct biological signatures associating specific ions with specific biological responses due to radiation exposure in space. For example, we discovered changes in mitochondrial function, ribosomal assembly, and immune pathways as a function of dose. Conclusions: We provided a summary of how the GeneLab's rich database of omics experiments with animal models can be used to generate novel hypotheses to better understand human health risks from GCR exposures.

Original languageEnglish
Article number381
Number of pages24
JournalCancers
Volume12
Issue number2
DOIs
Publication statusPublished - 07 Feb 2020

    Fingerprint

Cite this

McDonald, J. T., Stainforth, R., Miller, J., Cahill, T., da Silveira, W. A., Rathi, K. S., Hardiman, G., Taylor, D., Costes, S. V., Chauhan, V., Meller, R., & Beheshti, A. (2020). NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models. Cancers, 12(2), [381]. https://doi.org/10.3390/cancers12020381