Nematode neuropeptides: Localization, isolation and functions

D.J.A. Brownlee, Ian Fairweather, L. HoldenDye, R.J. Walker

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Historically, peptidergic substances (in the form of neurosecretions) were linked to moulting in nematodes. More recently, there has been a renewal of interest in nematode neurobiology, initially triggered by studies demonstrating the localization of peptide immunoreactivities to the nervous system. Here, David Brownlee, Ian Fairweather, Lindy Holden-Dye and Robert Walker will review progress on the isolation of nematode neuropeptides and efforts to unravel their physiological actions and inactivation mechanisms. Future avenues for research are suggested and the potential exploitation of peptidergic pathways in future therapeutic strategies highlighted.
Original languageEnglish
Pages (from-to)343-351
Number of pages9
JournalParasitology Today
Publication statusPublished - 1996


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