TY - JOUR
T1 - Neonatal procedural pain exposure predicts lower cortisol and behavioral reactivity in preterm infants in the NICU
AU - Grunau, Ruth E
AU - Holsti, Liisa
AU - Haley, David W
AU - Oberlander, Tim
AU - Weinberg, Joanne
AU - Solimano, Alfonso
AU - Whitfield, Michael F
AU - Fitzgerald, Colleen
AU - Yu, Wayne
PY - 2005
Y1 - 2005
N2 - Data from animal models indicate that neonatal stress or pain can permanently alter subsequent behavioral and/or physiological reactivity to stressors. However, cumulative effects of pain related to acute procedures in the neonatal intensive care unit (NICU) on later stress and/or pain reactivity has received limited attention. The objective of this study is to examine relationships between prior neonatal pain exposure (number of skin breaking procedures), and subsequent stress and pain reactivity in preterm infants in the NICU. Eighty-seven preterm infants were studied at 32 (+/-1 week) postconceptional age (PCA). Infants who received analgesia or sedation in the 72 h prior to each study, or any postnatal dexamethasone, were excluded. Outcomes were infant responses to two different stressors studied on separate days in a repeated measures randomized crossover design: (1) plasma cortisol to stress of a fixed series of nursing procedures; (2) behavioral (Neonatal Facial Coding System; NFCS) and cardiac reactivity to pain of blood collection. Among infants born
AB - Data from animal models indicate that neonatal stress or pain can permanently alter subsequent behavioral and/or physiological reactivity to stressors. However, cumulative effects of pain related to acute procedures in the neonatal intensive care unit (NICU) on later stress and/or pain reactivity has received limited attention. The objective of this study is to examine relationships between prior neonatal pain exposure (number of skin breaking procedures), and subsequent stress and pain reactivity in preterm infants in the NICU. Eighty-seven preterm infants were studied at 32 (+/-1 week) postconceptional age (PCA). Infants who received analgesia or sedation in the 72 h prior to each study, or any postnatal dexamethasone, were excluded. Outcomes were infant responses to two different stressors studied on separate days in a repeated measures randomized crossover design: (1) plasma cortisol to stress of a fixed series of nursing procedures; (2) behavioral (Neonatal Facial Coding System; NFCS) and cardiac reactivity to pain of blood collection. Among infants born
U2 - 10.1016/j.pain.2004.10.020
DO - 10.1016/j.pain.2004.10.020
M3 - Article
C2 - 15661436
VL - 113
SP - 293
EP - 300
JO - Pain
JF - Pain
SN - 0304-3959
IS - 3
ER -