Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking

Anne Hughes, N. Orr, Christopher Patterson, V. McConnell, Giuliana Silvestri, Usha Chakravarthy, Hossein Esfandiary, Ruth Hogg

Research output: Contribution to journalArticle

84 Citations (Scopus)
310 Downloads (Pure)

Abstract

Age-related macular degeneration (AMD) is the major cause of blindness in the elderly. Those with the neovascular end-stage of disease have irreversible loss of central vision. AMD is a complex disorder in which genetic and environmental factors play a role. Polymorphisms in the complement factor H (CFH) gene, LOC387715, and the HTRA1 promoter are strongly associated with AMD. Smoking also contributes to the etiology. We aimed to provide a model of disease risk based on these factors.
Original languageEnglish
Pages (from-to)e355
Number of pages8
JournalPLoS Medicine
Volume4
Issue number12
DOIs
Publication statusPublished - Dec 2007

ASJC Scopus subject areas

  • Medicine(all)

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