Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking

Anne Hughes; N. Orr; Christopher Patterson; V. McConnell; Giuliana Silvestri; Usha Chakravarthy; Hossein Esfandiary; Ruth Hogg

doi:10.1371/journal.pmed.0040355

Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking

Anne Hughes
, N. Orr
, Christopher Patterson
, V. McConnell
, Giuliana Silvestri
, Usha Chakravarthy
, Hossein Esfandiary
, Ruth Hogg

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

416 Downloads (Pure)

Abstract

Age-related macular degeneration (AMD) is the major cause of blindness in the elderly. Those with the neovascular end-stage of disease have irreversible loss of central vision. AMD is a complex disorder in which genetic and environmental factors play a role. Polymorphisms in the complement factor H (CFH) gene, LOC387715, and the HTRA1 promoter are strongly associated with AMD. Smoking also contributes to the etiology. We aimed to provide a model of disease risk based on these factors.

Original language	English
Pages (from-to)	e355
Number of pages	8
Journal	PLoS Medicine
Volume	4
Issue number	12
DOIs	https://doi.org/10.1371/journal.pmed.0040355
Publication status	Published - Dec 2007

ASJC Scopus subject areas

General Medicine

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Neovascular Age-Related Macular Degeneration Risk Based on CFH, LOC387715/HTRA1, and SmokingFinal published version, 222 KB

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title = "Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking",

abstract = "Age-related macular degeneration (AMD) is the major cause of blindness in the elderly. Those with the neovascular end-stage of disease have irreversible loss of central vision. AMD is a complex disorder in which genetic and environmental factors play a role. Polymorphisms in the complement factor H (CFH) gene, LOC387715, and the HTRA1 promoter are strongly associated with AMD. Smoking also contributes to the etiology. We aimed to provide a model of disease risk based on these factors.",

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AU - Hughes, Anne

AU - Orr, N.

AU - Patterson, Christopher

AU - McConnell, V.

AU - Silvestri, Giuliana

AU - Chakravarthy, Usha

AU - Esfandiary, Hossein

AU - Hogg, Ruth

PY - 2007/12

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AB - Age-related macular degeneration (AMD) is the major cause of blindness in the elderly. Those with the neovascular end-stage of disease have irreversible loss of central vision. AMD is a complex disorder in which genetic and environmental factors play a role. Polymorphisms in the complement factor H (CFH) gene, LOC387715, and the HTRA1 promoter are strongly associated with AMD. Smoking also contributes to the etiology. We aimed to provide a model of disease risk based on these factors.

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U2 - 10.1371/journal.pmed.0040355

DO - 10.1371/journal.pmed.0040355

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JO - PLoS Medicine

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ER -

Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking

Abstract

ASJC Scopus subject areas

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