Nephropathy in a hypercholesterolemic mouse model with streptozotocin-induced diabetes

Samar M Hammad, Debra J Hazen-Martin, Mimi Sohn, Leslie Eldridge, Lyn Powell-Braxton, Wesley Won, Timothy J Lyons

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


The contribution of preexisting hypercholesterolemia to diabetic nephropathy remains unclear. We assessed the impact of hypercholesterolemia on diabetic nephropathy using a double knockout (DKO) mouse, null for the low-density lipoprotein receptor (LDLRNDASH;/NDASH;) and the apoB mRNA editing catalytic polypeptide 1 (APOBEC1NDASH;/NDASH;).
Original languageEnglish
Pages (from-to)351-61
Number of pages11
JournalKidney & blood pressure research
Issue number5-6
Publication statusPublished - 2003

Bibliographical note

Copyright 2003 S. Karger AG, Basel


  • Albuminuria
  • Animals
  • Arteriosclerosis
  • Basement Membrane
  • Collagen
  • Cytidine Deaminase
  • Diabetes Mellitus, Experimental
  • Diabetic Nephropathies
  • Disease Models, Animal
  • Hypercholesterolemia
  • Kidney
  • Kidney Tubules
  • Lipid Metabolism
  • Lipids
  • Male
  • Mice
  • Mice, Knockout
  • Microscopy, Electron
  • Receptors, LDL
  • Streptozocin

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