Neural correlates of task switching in paternal 15q11-q13 deletion Prader-Willi syndrome

Kate A. Woodcock*, Glyn W. Humphreys, Chris Oliver, Peter C. Hansen

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We report a first study of brain activity linked to task switching in individuals with Prader-Willi syndrome (PWS) PWS individuals show a specific cognitive deficit in task switching which may be associated with the display of temper outbursts and repetitive questioning The performance of participants with PWS and typically developing controls was matched in a cued task switching procedure and brain activity was contrasted on switching and non switching blocks using SARI Individuals with PWS did not show the typical frontal-parietal pattern of neural activity associated with switching blocks, with significantly reduced activation in regions of the posterior parietal and ventromedial prefrontal cortices We suggest that this is linked to a difficulty in PWS in setting appropriate attentional weights to enable task set reconfiguration In addition to this, PWS individuals did not show the typical pattern of deactivation, with significantly less deactivation in an anterior region of the ventromedial prefrontal cortex One plausible explanation for this is that individuals with PWS show dysfunction within the default mode network which has been linked to attentional control The data point to functional changes in the neural circuitry supporting task switching in PWS even when behavioural performance is matched to controls and thus highlight neural mechanisms that may be involved in a specific pathway between genes cognition and behaviour (C) 2010 Elsevier B V All rights reserved

Original languageEnglish
Pages (from-to)128-142
Number of pages15
JournalBrain Research
Volume1363
DOIs
Publication statusPublished - 06 Dec 2010

Keywords

  • Prader-Willi syndrome
  • Task switching
  • Functional magnetic resonance imaging (fMRI)
  • Frontal-parietal neural activity
  • Behaviour
  • Default mode network
  • FRAGILE-X-SYNDROME
  • FMR1 GENE-EXPRESSION
  • COGNITIVE CONTROL
  • FUNCTIONAL CONNECTIVITY
  • WORKING-MEMORY
  • RESTING-STATE
  • BRAIN IMAGES
  • MECHANISMS
  • CORTEX
  • DYSFUNCTION

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