Neural dysfunction following respiratory viral infection as a cause of chronic cough hypersensitivity

Bradley J Undem, Eric Zaccone, Lorcan McGarvey, Stuart B Mazzone

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Respiratory viral infections are a common cause of acute coughing, an irritating symptom for the patient and an important mechanism of transmission for the virus. Although poorly described, the inflammatory consequences of infection likely induce coughing by chemical (inflammatory mediator) or mechanical (mucous) activation of the cough-evoking sensory nerves that innervate the airway wall. For some individuals, acute cough can evolve into a chronic condition, in which cough and aberrant airway sensations long outlast the initial viral infection. This suggests that some viruses have the capacity to induce persistent plasticity in the neural pathways mediating cough. In this brief review we present the clinical evidence of acute and chronic neural dysfunction following viral respiratory tract infections and explore possible mechanisms by which the nervous system may undergo activation, sensitization and plasticity.

Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalPulmonary Pharmacology and Therapeutics
Volume33
Early online date30 Jun 2015
DOIs
Publication statusPublished - 01 Aug 2015

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