Neurocognitive outcomes in adults following cerebral hypoxia: A systematic literature review

Naomi N M Brownlee; F Colin Wilson; David B Curran; Nigel Lyttle; John P McCann

doi:10.3233/NRE-203135

Neurocognitive outcomes in adults following cerebral hypoxia: A systematic literature review

Naomi N M Brownlee, F Colin Wilson, David B Curran, Nigel Lyttle, John P McCann

Research output: Contribution to journal › Review article

Abstract

BACKGROUND: Hypoxic ischemic brain injury (HIBI) occurs as a result of complete or partial disruption of cerebral oxygen supply. The physical and cognitive sequelae of adults following hypoxia varies widely.

OBJECTIVE: To systematically review studies exploring the neuropsychological outcomes following hypoxic brain insult in adults.

METHODS: Data was sourced using six databases (CINAHL, Cochrane, Embase, Medline, PsycInfo and Web of Science). Initial MESH terms identified 2,962 articles. After a three-stage independent review process, 18 articles, 9 case studies and 9 group studies were available for data synthesis from 1990-2012. Case study data was converted to standardised scores and compared to available test norms. Cohen's d was calculated to permit group data interpretation.

RESULTS: Intellectual decrement was observed in some studies although difficult to delineate given the lack of use of measures of premorbid ability. Cognitive sequelae varied albeit with predominant disturbance in verbal memory, learning ability and executive function observed across studies. Wechsler Memory Scale Revised (WMS-R) visual memory was comparable to normative data. Impaired Rey Osterrieth Complex Figure (ROCFT) performance was found among group studies. Across visuo-constructional and attention domains, performance varied, although no significant difference relative to reported means was observed.

CONCLUSIONS: Future studies should consider the use of standardised assessment protocols, which include measures of premorbid functioning and performance validity.

Original language	English
Journal	NeuroRehabilitation
Early online date	21 Jul 2020
DOIs	https://doi.org/10.3233/NRE-203135
Publication status	Early online date - 21 Jul 2020

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@article{fe48ab160c7c4a2892dec93ff6a6487d,

title = "Neurocognitive outcomes in adults following cerebral hypoxia: A systematic literature review",

abstract = "BACKGROUND: Hypoxic ischemic brain injury (HIBI) occurs as a result of complete or partial disruption of cerebral oxygen supply. The physical and cognitive sequelae of adults following hypoxia varies widely.OBJECTIVE: To systematically review studies exploring the neuropsychological outcomes following hypoxic brain insult in adults.METHODS: Data was sourced using six databases (CINAHL, Cochrane, Embase, Medline, PsycInfo and Web of Science). Initial MESH terms identified 2,962 articles. After a three-stage independent review process, 18 articles, 9 case studies and 9 group studies were available for data synthesis from 1990-2012. Case study data was converted to standardised scores and compared to available test norms. Cohen's d was calculated to permit group data interpretation.RESULTS: Intellectual decrement was observed in some studies although difficult to delineate given the lack of use of measures of premorbid ability. Cognitive sequelae varied albeit with predominant disturbance in verbal memory, learning ability and executive function observed across studies. Wechsler Memory Scale Revised (WMS-R) visual memory was comparable to normative data. Impaired Rey Osterrieth Complex Figure (ROCFT) performance was found among group studies. Across visuo-constructional and attention domains, performance varied, although no significant difference relative to reported means was observed.CONCLUSIONS: Future studies should consider the use of standardised assessment protocols, which include measures of premorbid functioning and performance validity.",

author = "Brownlee, {Naomi N M} and Wilson, {F Colin} and Curran, {David B} and Nigel Lyttle and McCann, {John P}",

year = "2020",

month = jul,

day = "21",

doi = "10.3233/NRE-203135",

language = "English",

journal = "NeuroRehabilitation",

issn = "1053-8135",

publisher = "IOS Press",

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TY - JOUR

T1 - Neurocognitive outcomes in adults following cerebral hypoxia: A systematic literature review

AU - Brownlee, Naomi N M

AU - Wilson, F Colin

AU - Curran, David B

AU - Lyttle, Nigel

AU - McCann, John P

PY - 2020/7/21

Y1 - 2020/7/21

N2 - BACKGROUND: Hypoxic ischemic brain injury (HIBI) occurs as a result of complete or partial disruption of cerebral oxygen supply. The physical and cognitive sequelae of adults following hypoxia varies widely.OBJECTIVE: To systematically review studies exploring the neuropsychological outcomes following hypoxic brain insult in adults.METHODS: Data was sourced using six databases (CINAHL, Cochrane, Embase, Medline, PsycInfo and Web of Science). Initial MESH terms identified 2,962 articles. After a three-stage independent review process, 18 articles, 9 case studies and 9 group studies were available for data synthesis from 1990-2012. Case study data was converted to standardised scores and compared to available test norms. Cohen's d was calculated to permit group data interpretation.RESULTS: Intellectual decrement was observed in some studies although difficult to delineate given the lack of use of measures of premorbid ability. Cognitive sequelae varied albeit with predominant disturbance in verbal memory, learning ability and executive function observed across studies. Wechsler Memory Scale Revised (WMS-R) visual memory was comparable to normative data. Impaired Rey Osterrieth Complex Figure (ROCFT) performance was found among group studies. Across visuo-constructional and attention domains, performance varied, although no significant difference relative to reported means was observed.CONCLUSIONS: Future studies should consider the use of standardised assessment protocols, which include measures of premorbid functioning and performance validity.

AB - BACKGROUND: Hypoxic ischemic brain injury (HIBI) occurs as a result of complete or partial disruption of cerebral oxygen supply. The physical and cognitive sequelae of adults following hypoxia varies widely.OBJECTIVE: To systematically review studies exploring the neuropsychological outcomes following hypoxic brain insult in adults.METHODS: Data was sourced using six databases (CINAHL, Cochrane, Embase, Medline, PsycInfo and Web of Science). Initial MESH terms identified 2,962 articles. After a three-stage independent review process, 18 articles, 9 case studies and 9 group studies were available for data synthesis from 1990-2012. Case study data was converted to standardised scores and compared to available test norms. Cohen's d was calculated to permit group data interpretation.RESULTS: Intellectual decrement was observed in some studies although difficult to delineate given the lack of use of measures of premorbid ability. Cognitive sequelae varied albeit with predominant disturbance in verbal memory, learning ability and executive function observed across studies. Wechsler Memory Scale Revised (WMS-R) visual memory was comparable to normative data. Impaired Rey Osterrieth Complex Figure (ROCFT) performance was found among group studies. Across visuo-constructional and attention domains, performance varied, although no significant difference relative to reported means was observed.CONCLUSIONS: Future studies should consider the use of standardised assessment protocols, which include measures of premorbid functioning and performance validity.

U2 - 10.3233/NRE-203135

DO - 10.3233/NRE-203135

M3 - Review article

C2 - 32716324

JO - NeuroRehabilitation

JF - NeuroRehabilitation

SN - 1053-8135

ER -