Neuronal differentiation of adipose derived stem cells: Progress so far

T. J. Moore, Heidi Abrahamse*

*Corresponding author for this work

Research output: Contribution to journalReview article

4 Citations (Scopus)
87 Downloads (Pure)

Abstract

The nervous system is essential for normal physiological function of all systems within the human body. Unfortunately the nervous system has a limited capacity for self-repair and there are a plethora of disorders, diseases, and types of trauma that affect the central and peripheral nervous systems; however, current treatment modalities are unable to remedy them. Stem cell therapy using easily accessible mesenchymal stem cells, such as those found in the adipose stroma, has come to the fore in a number of biomedical disciplines as a potential therapeutic regime. In addition to substantial research already having been conducted on the in vitro differentiation of stem cells for the treatment of neurological repair, numerous strategies for the induction and culture of stem cells into terminal neural lineages have also been developed. However, none of these strategies have yet been able to produce a fully functional descendent suitable for use in stem cell therapy. Due to the positive effects that low level laser irradiation has shown in stem cell studies to date, we propose that it could enhance the processes involved in the differentiation of adipose derived stem cells into neuronal lineages.

Original languageEnglish
Article number827540
Number of pages8
JournalInternational Journal of Photoenergy
Volume2014
DOIs
Publication statusPublished - 30 Jul 2014

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stem cells
Stem cells
Neurology
nervous system
therapy
Repair
peripheral nervous system
central nervous system
human body
Laser beam effects
Cell culture
induction
disorders
irradiation
lasers

Cite this

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abstract = "The nervous system is essential for normal physiological function of all systems within the human body. Unfortunately the nervous system has a limited capacity for self-repair and there are a plethora of disorders, diseases, and types of trauma that affect the central and peripheral nervous systems; however, current treatment modalities are unable to remedy them. Stem cell therapy using easily accessible mesenchymal stem cells, such as those found in the adipose stroma, has come to the fore in a number of biomedical disciplines as a potential therapeutic regime. In addition to substantial research already having been conducted on the in vitro differentiation of stem cells for the treatment of neurological repair, numerous strategies for the induction and culture of stem cells into terminal neural lineages have also been developed. However, none of these strategies have yet been able to produce a fully functional descendent suitable for use in stem cell therapy. Due to the positive effects that low level laser irradiation has shown in stem cell studies to date, we propose that it could enhance the processes involved in the differentiation of adipose derived stem cells into neuronal lineages.",
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Neuronal differentiation of adipose derived stem cells : Progress so far. / Moore, T. J.; Abrahamse, Heidi.

In: International Journal of Photoenergy, Vol. 2014, 827540, 30.07.2014.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Neuronal differentiation of adipose derived stem cells

T2 - Progress so far

AU - Moore, T. J.

AU - Abrahamse, Heidi

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