Neuropeptides regulate expression of angiogenic growth factors in human dental pulp fibroblasts

Ikhlas A. El Karim*, Gerard J. Linden, Chris R. Irwin, Fionnuala T. Lundy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Neuropeptides play an important role in inflammation and repair and have been implicated in mediating angiogenesis. Pulp fibroblasts express neuropeptide receptors, and the aim of this research was to investigate whether neuropeptides could regulate angiogenic growth factor expression in vitro.

An angiogenic array was used to determine the levels of 10 angiogenic growth factors expressed by human pulp fibroblasts.

Pulp fibroblasts were shown to express angiogenin, angiopoietin-2, epidermal growth factor, basic fibroblast growth factor, heparin-binding epidermal growth factor, hepatocyte growth factor, leptin, platelet-derived growth factor, placental growth factor, and vascular endothelial growth factor. Furthermore, the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide, and neuropeptide Y altered angiogenic growth factor expression in vitro.

The regulation of angiogenic growth factor expression by neuropeptides suggests a novel role for neuropeptides in pulpal inflammation and repair.

Original languageEnglish
Pages (from-to)829-833
JournalJournal of Endodontics
Issue number6
Early online date20 Apr 2009
Publication statusPublished - 01 Jun 2009


  • Angiogenesis Modulating Agents
  • Angiogenic Proteins
  • Cells, Cultured
  • Dental Pulp
  • Fibroblasts
  • Growth Substances
  • Humans
  • Neovascularization, Physiologic
  • Neuropeptides
  • Up-Regulation


Dive into the research topics of 'Neuropeptides regulate expression of angiogenic growth factors in human dental pulp fibroblasts'. Together they form a unique fingerprint.

Cite this