Neutrophils and the inflammatory tissue microenvironment in the mucosa

Eric L. Campbell*, Daniel J. Kao, Sean P. Colgan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


The interaction of neutrophils (PMNs) and epithelial cells are requisite lines of communication during mucosal inflammatory responses. Consequences of such interactions often determine endpoint organ function, and for this reason, much interest has developed around defining the constituents of the tissue microenvironment of inflammatory lesions. Physiologic in vitro and in vivo models have aided in the discovery of components that define the basic inflammatory machinery that mold the inflammatory tissue microenvironment. Here, we will review the recent literature related to the contribution of PMNs to molding of the tissue microenvironment, with an emphasis on the gastrointestinal (GI) tract. We focus on endogenous pathways for promoting tissue homeostasis and the molecular determinants of neutrophil–epithelial cell interactions during ongoing inflammation. These recent studies highlight the dynamic nature of these pathways and lend insight into the complexity of treating mucosal inflammation.

Original languageEnglish
Pages (from-to)112-120
Number of pages9
JournalImmunological Reviews
Issue number1
Publication statusPublished - 01 Sep 2016
Externally publishedYes


  • colitis
  • epithelium
  • hypoxia-inducible factor
  • inflammation
  • metabolism
  • mucosa
  • nucleoside
  • nucleotidase

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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