New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity.

Shozeb Haider

doi:10.1039/c2cc34399a

New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity.

Shozeb Haider

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

This communication reports on the synthesis and biophysical, biological and SAR studies of a small library of new anti-HIV aptamers based on the tetra-end-linked G-quadruplex structure. The new aptamers showed EC(50) values against HIV-1 in the range of 0.04-0.15 µM as well as affinities for the HIV-1 gp120 envelope in the same order of magnitude

Original language	English
Pages (from-to)	9516-9518
Number of pages	2
Journal	Chemical Communications
Volume	48
Issue number	76
DOIs	https://doi.org/10.1039/c2cc34399a
Publication status	Published - 04 Oct 2012

ASJC Scopus subject areas

Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Catalysis
General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c2cc34399a

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AB - This communication reports on the synthesis and biophysical, biological and SAR studies of a small library of new anti-HIV aptamers based on the tetra-end-linked G-quadruplex structure. The new aptamers showed EC(50) values against HIV-1 in the range of 0.04-0.15 µM as well as affinities for the HIV-1 gp120 envelope in the same order of magnitude

U2 - 10.1039/c2cc34399a

DO - 10.1039/c2cc34399a

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New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity.

Abstract

ASJC Scopus subject areas

UN SDGs

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