Abstract
This communication reports on the synthesis and biophysical, biological and SAR studies of a small library of new anti-HIV aptamers based on the tetra-end-linked G-quadruplex structure. The new aptamers showed EC(50) values against HIV-1 in the range of 0.04-0.15 µM as well as affinities for the HIV-1 gp120 envelope in the same order of magnitude
| Original language | English |
|---|---|
| Pages (from-to) | 9516-9518 |
| Number of pages | 2 |
| Journal | Chemical Communications |
| Volume | 48 |
| Issue number | 76 |
| DOIs | |
| Publication status | Published - 04 Oct 2012 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
ASJC Scopus subject areas
- Metals and Alloys
- Materials Chemistry
- Surfaces, Coatings and Films
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Catalysis
- General Chemistry
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