New Approaches to the Total Synthesis of the Bryostatin Antitumour Macrolides

Karl J Hale, Soraya Manaviazar

Research output: Contribution to journalArticlepeer-review

108 Citations (Scopus)

Abstract

In this Focus Review, we give an overview of various bryostatin total syntheses. We also discuss the synthesis of various bryostatin analogues and their biological activity. Work reviewed includes that of Masamune, Evans, Nishiyama and Yamamura, Hale and Manaviazar, Trost, Wender, Keck, Burke, Thomas, and Krische. Our coverage is primarily for the period 2001–2009, since detailed reviews already exist on bryostatin total synthesis work and biology up to this time.
Original languageEnglish
Pages (from-to)704-754
Number of pages51
JournalCHEMISTRY-AN ASIAN JOURNAL
Volume5
Issue number4
DOIs
Publication statusPublished - 01 Apr 2010

ASJC Scopus subject areas

  • General Chemistry
  • General Medicine

Fingerprint

Dive into the research topics of 'New Approaches to the Total Synthesis of the Bryostatin Antitumour Macrolides'. Together they form a unique fingerprint.

Cite this