New Approaches to the Total Synthesis of the Bryostatin Antitumour Macrolides

Karl J Hale; Soraya Manaviazar

doi:10.1002/asia.200900634

New Approaches to the Total Synthesis of the Bryostatin Antitumour Macrolides

Karl J Hale, Soraya Manaviazar

Research output: Contribution to journal › Article › peer-review

112 Citations (Scopus)

Abstract

In this Focus Review, we give an overview of various bryostatin total syntheses. We also discuss the synthesis of various bryostatin analogues and their biological activity. Work reviewed includes that of Masamune, Evans, Nishiyama and Yamamura, Hale and Manaviazar, Trost, Wender, Keck, Burke, Thomas, and Krische. Our coverage is primarily for the period 2001–2009, since detailed reviews already exist on bryostatin total synthesis work and biology up to this time.

Original language	English
Pages (from-to)	704-754
Number of pages	51
Journal	CHEMISTRY-AN ASIAN JOURNAL
Volume	5
Issue number	4
DOIs	https://doi.org/10.1002/asia.200900634
Publication status	Published - 01 Apr 2010

ASJC Scopus subject areas

General Chemistry
General Medicine

Access to Document

10.1002/asia.200900634

Cite this

@article{dd42bdc5e1f14794a447c3662d688bf0,

title = "New Approaches to the Total Synthesis of the Bryostatin Antitumour Macrolides",

abstract = "In this Focus Review, we give an overview of various bryostatin total syntheses. We also discuss the synthesis of various bryostatin analogues and their biological activity. Work reviewed includes that of Masamune, Evans, Nishiyama and Yamamura, Hale and Manaviazar, Trost, Wender, Keck, Burke, Thomas, and Krische. Our coverage is primarily for the period 2001–2009, since detailed reviews already exist on bryostatin total synthesis work and biology up to this time.",

author = "Hale, {Karl J} and Soraya Manaviazar",

year = "2010",

month = apr,

day = "1",

doi = "10.1002/asia.200900634",

language = "English",

volume = "5",

pages = "704--754",

journal = "CHEMISTRY-AN ASIAN JOURNAL",

issn = "1861-471X",

publisher = "John Wiley & Sons Ltd",

number = "4",

}

TY - JOUR

T1 - New Approaches to the Total Synthesis of the Bryostatin Antitumour Macrolides

AU - Hale, Karl J

AU - Manaviazar, Soraya

PY - 2010/4/1

Y1 - 2010/4/1

N2 - In this Focus Review, we give an overview of various bryostatin total syntheses. We also discuss the synthesis of various bryostatin analogues and their biological activity. Work reviewed includes that of Masamune, Evans, Nishiyama and Yamamura, Hale and Manaviazar, Trost, Wender, Keck, Burke, Thomas, and Krische. Our coverage is primarily for the period 2001–2009, since detailed reviews already exist on bryostatin total synthesis work and biology up to this time.

AB - In this Focus Review, we give an overview of various bryostatin total syntheses. We also discuss the synthesis of various bryostatin analogues and their biological activity. Work reviewed includes that of Masamune, Evans, Nishiyama and Yamamura, Hale and Manaviazar, Trost, Wender, Keck, Burke, Thomas, and Krische. Our coverage is primarily for the period 2001–2009, since detailed reviews already exist on bryostatin total synthesis work and biology up to this time.

U2 - 10.1002/asia.200900634

DO - 10.1002/asia.200900634

M3 - Article

SN - 1861-471X

VL - 5

SP - 704

EP - 754

JO - CHEMISTRY-AN ASIAN JOURNAL

JF - CHEMISTRY-AN ASIAN JOURNAL

IS - 4

ER -

New Approaches to the Total Synthesis of the Bryostatin Antitumour Macrolides

Abstract

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this