New insights into the FLPergic complements of parasitic nematodes: Informing deorphanisation approaches

Ciaran J. McCoy, Louise E. Atkinson, Mostafa Zamanian, Paul McVeigh, Tim A. Day, Michael J. Kimber, Nikki J. Marks, Aaron G. Maule, Angela Mousley*

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Citations (Scopus)
269 Downloads (Pure)

Abstract

FMRFamide-like peptide (FLP) receptors are appealing as putative anthelmintic targets. To date, 31 flp-encoding genes have been identified in Caenorhabditis elegans and thirteen FLP-activated G-protein coupled receptors (FLP-GPCRs) have been reported. The lack of knowledge on FLPs and FLP-GPCRs in parasites impedes their functional characterisation and chemotherapeutic exploitation. Using homology-based BLAST searches and phylogenetic analyses this study describes the identification of putative flp and flp-GPCR gene homologues in 17 nematode parasites providing the first pan-phylum genome-based overview of the FLPergic complement. These data will facilitate FLP-receptor deorphanisation efforts in the quest for novel control targets for nematode parasites.
Original languageEnglish
Pages (from-to)262-272
Number of pages11
JournalEuPA Open Proteomics
Volume3
Early online date19 Apr 2014
DOIs
Publication statusPublished - Jun 2014

Keywords

  • FLP
  • FLP-receptor
  • FMRFamide-like peptide
  • Nematode
  • Neuropeptide GPCR

ASJC Scopus subject areas

  • Biochemistry

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