FMRFamide-like peptide (FLP) receptors are appealing as putative anthelmintic targets. To date, 31 flp-encoding genes have been identified in Caenorhabditis elegans and thirteen FLP-activated G-protein coupled receptors (FLP-GPCRs) have been reported. The lack of knowledge on FLPs and FLP-GPCRs in parasites impedes their functional characterisation and chemotherapeutic exploitation. Using homology-based BLAST searches and phylogenetic analyses this study describes the identification of putative flp and flp-GPCR gene homologues in 17 nematode parasites providing the first pan-phylum genome-based overview of the FLPergic complement. These data will facilitate FLP-receptor deorphanisation efforts in the quest for novel control targets for nematode parasites.
- FMRFamide-like peptide
- Neuropeptide GPCR
ASJC Scopus subject areas
McCoy, C. J., Atkinson, L. E., Zamanian, M., McVeigh, P., Day, T. A., Kimber, M. J., Marks, N. J., Maule, A. G., & Mousley, A. (2014). New insights into the FLPergic complements of parasitic nematodes: Informing deorphanisation approaches. EuPA Open Proteomics, 3, 262-272. https://doi.org/10.1016/j.euprot.2014.04.002