New insights into the regulation of signalling by toll-like receptors and nod-like receptors

Rebecca C. Coll, Luke A.J. O'Neill

Research output: Contribution to journalReview article

100 Citations (Scopus)

Abstract

The activation of Toll-Like receptors (TLRs) and Nod-like receptors (NLRs) triggers intracellular signalling pathways that lead to effector mechanisms in innate immunity and inflammation. The negative regulation of TLR signalling has been extensively studied. Current areas of research include post-transcriptional regulation by miRNA, post-translational regulation by ubiquitination and regulation by splice variants such as MyD88s, TRAM adaptor with GOLD domain and IRAK2 isoforms. The negative regulation of NLR signalling is a relatively new area of research. Examples include a splice variant of NOD2, the ubiquitin editing enzyme A20, pyrin domain-only proteins and caspase recruitment domain-only proteins which all have a negative effect on NOD2 or NLRP3 signalling. A greater understanding of the mechanisms underlying the negative control of TLR and NLR signalling may provide new targets for therapeutic intervention.

Original languageEnglish
Pages (from-to)406-421
Number of pages16
JournalJournal of innate immunity
Volume2
Issue number5
DOIs
Publication statusPublished - 01 Aug 2010
Externally publishedYes

Keywords

  • miRNA
  • Negative regulation
  • Nod-like receptor
  • Toll-like receptor
  • Ubiquitination

ASJC Scopus subject areas

  • Immunology and Allergy

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