New measure of health-related quality of life for patients with oropharyngeal mucositis: Development and preliminary psychometric evaluation

Karis Kin Fong Cheng*, S. F. Leung, Josepha W.M. Tai, Raymond H.S. Liang, Alta S.T. Kan, Fion W.O. Ying, Rebecca M.W. Yeung, David, R Thompson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

BACKGROUND. Oropharyngeal mucositis (OM) causes profound impairment of patients' health-related quality of life (HQoL). The aim of the article is to describe the development and preliminary validation of an HQoL instrument, OMQoL, specifically for patients with OM. METHODS. First, a qualitative phase was conducted to generate items (n = 23). Face validity was assessed by focus group interviews (n = 13). Expert content review (n = 7) was used to ensure content validity. The second step was a quantitative validation phase comprised a multicenter study (n = 210) to help identify subscales of the instrument addressing different dimensions of OM and to measure reliability. RESULTS. The qualitative interview generated 171 items. Using focus group discussion and expert content review, items were reduced to 41 items. Factor and scaling analyses of these 41 items resulted in 4 subscales, contributed by 31 items, depicting problems with symptoms, diet, social function, and swallowing. The floor effect was modest. The factorial structure was satisfactory with loading >0.40 on each subscale for all items. All corrected item-total corrections were higher than 0.40 (r = 0.457-0.874). The internal consistency reliability of each subscale was high, with Cronbach alpha coefficients ranging from 0.906 to 0.934. The test-retest reliability of the individual items using weighted kappa was good (kappa values 0.610-0.895). The intraclass correlation results for the subscale totals were all in excess of 0.70 (0.864-0.934). CONCLUSIONS. An initial psychometric analysis of the OMQoL was encouraging. The OMQoL could provide a valuable tool for the assessment of HQoL of patients with OM.

Original languageEnglish
Pages (from-to)2590-2599
Number of pages10
JournalCancer
Volume109
Issue number12
DOIs
Publication statusPublished - 15 Jun 2007

Keywords

  • Cancer treatment
  • Health-related quality of life
  • Oropharyngeal mucositis
  • Psychometric properties

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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