Abstract
We describe new methodology for the synthesis of symmetric bis-benzimidazole carrying 2-aryl moieties, including 2-[4-3'-aminopropoxy)phenyl] and 2-[4-(3'-aminopropanamido)pheny] substituents, together with the synthesis of novel hybrid molecules comprising bis-benzimidazoles in ester and amide combination with the N-mustard chlorambucil. The in vitro activities of these compounds against five cancer cell lines are also provided.
Original language | English |
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Pages (from-to) | 1305-1312 |
Number of pages | 8 |
Journal | Organic and Biomolecular Chemistry |
Volume | 4 |
Issue number | 7 |
DOIs | |
Publication status | Published - Apr 2006 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Chemistry(all)