New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity

Christine Le Sann; J. Mann; S. Neidle; Hendrik Van Den Berg; M. Gunaratnam; A. Baron

doi:10.1039/b600567e

New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity

Christine Le Sann, J. Mann, S. Neidle, Hendrik Van Den Berg, M. Gunaratnam, A. Baron

Research output: Contribution to journal › Article

40 Citations (Scopus)

Abstract

We describe new methodology for the synthesis of symmetric bis-benzimidazole carrying 2-aryl moieties, including 2-[4-3'-aminopropoxy)phenyl] and 2-[4-(3'-aminopropanamido)pheny] substituents, together with the synthesis of novel hybrid molecules comprising bis-benzimidazoles in ester and amide combination with the N-mustard chlorambucil. The in vitro activities of these compounds against five cancer cell lines are also provided.

Original language	English
Pages (from-to)	1305-1312
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	4
Issue number	7
DOIs	https://doi.org/10.1039/b600567e
Publication status	Published - Apr 2006

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Chemistry(all)

Access to Document

10.1039/b600567e

Link to publication in Scopus

Fingerprint Dive into the research topics of 'New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity'. Together they form a unique fingerprint.

Cite this

Le Sann, C., Mann, J., Neidle, S., Van Den Berg, H., Gunaratnam, M., & Baron, A. (2006). New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity. Organic and Biomolecular Chemistry, 4(7), 1305-1312. https://doi.org/10.1039/b600567e

@article{1b203a03595c43b3a3e5a364aa5bdf13,

title = "New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity",

abstract = "We describe new methodology for the synthesis of symmetric bis-benzimidazole carrying 2-aryl moieties, including 2-[4-3'-aminopropoxy)phenyl] and 2-[4-(3'-aminopropanamido)pheny] substituents, together with the synthesis of novel hybrid molecules comprising bis-benzimidazoles in ester and amide combination with the N-mustard chlorambucil. The in vitro activities of these compounds against five cancer cell lines are also provided.",

author = "{Le Sann}, Christine and J. Mann and S. Neidle and {Van Den Berg}, Hendrik and M. Gunaratnam and A. Baron",

year = "2006",

month = apr,

doi = "10.1039/b600567e",

language = "English",

volume = "4",

pages = "1305--1312",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "7",

}

TY - JOUR

T1 - New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity

AU - Le Sann, Christine

AU - Mann, J.

AU - Neidle, S.

AU - Van Den Berg, Hendrik

AU - Gunaratnam, M.

AU - Baron, A.

PY - 2006/4

Y1 - 2006/4

N2 - We describe new methodology for the synthesis of symmetric bis-benzimidazole carrying 2-aryl moieties, including 2-[4-3'-aminopropoxy)phenyl] and 2-[4-(3'-aminopropanamido)pheny] substituents, together with the synthesis of novel hybrid molecules comprising bis-benzimidazoles in ester and amide combination with the N-mustard chlorambucil. The in vitro activities of these compounds against five cancer cell lines are also provided.

AB - We describe new methodology for the synthesis of symmetric bis-benzimidazole carrying 2-aryl moieties, including 2-[4-3'-aminopropoxy)phenyl] and 2-[4-(3'-aminopropanamido)pheny] substituents, together with the synthesis of novel hybrid molecules comprising bis-benzimidazoles in ester and amide combination with the N-mustard chlorambucil. The in vitro activities of these compounds against five cancer cell lines are also provided.

UR - http://www.scopus.com/inward/record.url?scp=33645301887&partnerID=8YFLogxK

U2 - 10.1039/b600567e

DO - 10.1039/b600567e

M3 - Article

VL - 4

SP - 1305

EP - 1312

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 7

ER -