New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity

Christine Le Sann, J. Mann, S. Neidle, Hendrik Van Den Berg, M. Gunaratnam, A. Baron

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

We describe new methodology for the synthesis of symmetric bis-benzimidazole carrying 2-aryl moieties, including 2-[4-3'-aminopropoxy)phenyl] and 2-[4-(3'-aminopropanamido)pheny] substituents, together with the synthesis of novel hybrid molecules comprising bis-benzimidazoles in ester and amide combination with the N-mustard chlorambucil. The in vitro activities of these compounds against five cancer cell lines are also provided.
Original languageEnglish
Pages (from-to)1305-1312
Number of pages8
JournalOrganic and Biomolecular Chemistry
Volume4
Issue number7
DOIs
Publication statusPublished - Apr 2006

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)

Fingerprint

Dive into the research topics of 'New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity'. Together they form a unique fingerprint.

Cite this