New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity

Christine Le Sann; J. Mann; S. Neidle; Hendrik Van Den Berg; M. Gunaratnam; A. Baron

doi:10.1039/b600567e

New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity

Christine Le Sann, J. Mann, S. Neidle, Hendrik Van Den Berg, M. Gunaratnam, A. Baron

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

We describe new methodology for the synthesis of symmetric bis-benzimidazole carrying 2-aryl moieties, including 2-[4-3'-aminopropoxy)phenyl] and 2-[4-(3'-aminopropanamido)pheny] substituents, together with the synthesis of novel hybrid molecules comprising bis-benzimidazoles in ester and amide combination with the N-mustard chlorambucil. The in vitro activities of these compounds against five cancer cell lines are also provided.

Original language	English
Pages (from-to)	1305-1312
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	4
Issue number	7
DOIs	https://doi.org/10.1039/b600567e
Publication status	Published - Apr 2006

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Chemistry(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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AU - Le Sann, Christine

AU - Mann, J.

AU - Neidle, S.

AU - Van Den Berg, Hendrik

AU - Gunaratnam, M.

AU - Baron, A.

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AB - We describe new methodology for the synthesis of symmetric bis-benzimidazole carrying 2-aryl moieties, including 2-[4-3'-aminopropoxy)phenyl] and 2-[4-(3'-aminopropanamido)pheny] substituents, together with the synthesis of novel hybrid molecules comprising bis-benzimidazoles in ester and amide combination with the N-mustard chlorambucil. The in vitro activities of these compounds against five cancer cell lines are also provided.

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New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity

Abstract

ASJC Scopus subject areas

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