We describe new methodology for the synthesis of symmetric bis-benzimidazole carrying 2-aryl moieties, including 2-[4-3'-aminopropoxy)phenyl] and 2-[4-(3'-aminopropanamido)pheny] substituents, together with the synthesis of novel hybrid molecules comprising bis-benzimidazoles in ester and amide combination with the N-mustard chlorambucil. The in vitro activities of these compounds against five cancer cell lines are also provided.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Le Sann, C., Mann, J., Neidle, S., Van Den Berg, H., Gunaratnam, M., & Baron, A. (2006). New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity. Organic and Biomolecular Chemistry, 4(7), 1305-1312. https://doi.org/10.1039/b600567e