Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population

Adam P. Douglas, Dwaine R. Vance, Elaine M. Kenny, Derek W. Morris, Alexander P. Maxwell, Amy Jayne McKnight

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)
204 Downloads (Pure)

Abstract

Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100).

Original languageEnglish
Pages (from-to)7379
JournalScientific Reports
Volume4
DOIs
Publication statusPublished - 09 Dec 2014

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