Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population

Adam P. Douglas; Dwaine R. Vance; Elaine M. Kenny; Derek W. Morris; Alexander P. Maxwell; Amy Jayne McKnight

doi:10.1038/srep07379

Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population

Adam P. Douglas, Dwaine R. Vance, Elaine M. Kenny, Derek W. Morris, Alexander P. Maxwell, Amy Jayne McKnight

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Abstract

Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100).

Original language	English
Pages (from-to)	7379
Journal	Scientific Reports
Volume	4
DOIs	https://doi.org/10.1038/srep07379
Publication status	Published - 09 Dec 2014

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10.1038/srep07379

Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population
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title = "Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population",

abstract = "Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100).",

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AU - Maxwell, Alexander P.

AU - McKnight, Amy Jayne

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AB - Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100).

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Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population

Abstract

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