Nickel tetrazolato complexes synthesized by microwave irradiation: Catecholase like activity and interaction with biomolecules

Novina Malviya, Poulami Mandal, Mriganka Das, Rakesh Ganguly, Suman Mukhopadhyay

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

1,3-Dipolar cycloaddition between nickel-ligated azide in [NiL(N3)] [HL = 3-(2-diethylamino-ethylimino)-1-phenyl-butan-1-one] and two different organonitriles furnished two new square-planar complexes viz. [NiL(5-phenyltetrazolato)] and [NiL{5-(4-pyridyl)-tetrazolato}]. Both the complexes have been characterized by spectroscopic tools and single-crystal X-ray crystallography. Interaction with different biomolecules revealed that both complexes bind strongly to serum albumin proteins and show moderate catecholase-like activity by catalyzing the oxidation of 3,5-ditertbutylcatechol (3,5-DTBC). Identification of intermediates formed in catechol oxidation has been explored by ESI-MS spectrometry.
Original languageEnglish
Pages (from-to)261-278
Number of pages18
JournalJournal of Coordination Chemistry
Volume70
Issue number2
Early online date28 Nov 2016
DOIs
Publication statusPublished - 17 Jan 2017
Externally publishedYes

Keywords

  • Nickel
  • catecholase activity
  • protein binding
  • tetrazolato complexes

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