Abstract
Benzimidazole-based nucleotides and dinucleotides have been synthesised to increase the range of chemical tools available to probe the NAD+ biology space. They were examined for their reactivity in alkylation-type reactions, where they yielded unstable alkylated heteoaromatic adducts, both chemically and enzymatically. While unsuited for NAD+ cyclases, these NAD+ analogues could be viable substrates for non-adenine modifying NAD+-dependent enzyme classes.
Original language | English |
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Pages (from-to) | 2331-2336 |
Journal | Synlett |
Volume | 25 |
Issue number | 16 |
Early online date | 26 Aug 2014 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- benzimidazoribosyl nucleosides
- cyclic adenosine diphosphoribose
- enzymes
- nucleotides
- phosphorylation
ASJC Scopus subject areas
- Organic Chemistry