Abstract
The UK is in the midst of a drug-related crisis. Likely contributory factors include: disinvestment in drug treatment, harm reduction, and public services; changing patterns of socioeconomic deprivation; increasing poly-drug use; and an ageing cohort of people who use heroin. The UK crisis has not reached the scale of that in the US where 106 699 overdose deaths were reported in 2021. The latest wave of the crisis in the US has been driven primarily by fentanyl and other synthetic opioids, which were implicated in 88% of these deaths.
Highly potent synthetic opioids have not played such a prominent role in rising deaths among people who use drugs in the UK. Global drug markets are, however, rapidly evolving. Of particular concern is the emergence of nitazenes: a class of synthetic opioids developed by the pharmaceutical industry in the 1950s but never approved as medicines. Like other opioids, nitazenes can cause fatal respiratory depression, and some are hundreds of times more potent than heroin (table). In the UK, nitazenes have been detected in substances sold as other opioids, benzodiazepines, and cannabis products. This means many consumers are using nitazenes inadvertently, unaware of the risks they face.
Highly potent synthetic opioids have not played such a prominent role in rising deaths among people who use drugs in the UK. Global drug markets are, however, rapidly evolving. Of particular concern is the emergence of nitazenes: a class of synthetic opioids developed by the pharmaceutical industry in the 1950s but never approved as medicines. Like other opioids, nitazenes can cause fatal respiratory depression, and some are hundreds of times more potent than heroin (table). In the UK, nitazenes have been detected in substances sold as other opioids, benzodiazepines, and cannabis products. This means many consumers are using nitazenes inadvertently, unaware of the risks they face.
Original language | English |
---|---|
Pages (from-to) | e71-e72 |
Number of pages | 2 |
Journal | The Lancet Public Health |
Volume | 9 |
Issue number | 2 |
Early online date | 12 Jan 2024 |
DOIs | |
Publication status | Published - Feb 2024 |
Fingerprint
Dive into the research topics of 'Nitazenes - heralding a second wave for the UK drug-related death crisis?'. Together they form a unique fingerprint.Press/Media
-
PODCAST: Reducing drug harms in the UK with Dr Gillian Shorter and Professor Alex Stevens
06/11/2024
1 Media contribution
Press/Media: Expert Comment
-
People buying opioids and sedatives online face deadly fakes, expert warns
17/01/2024
1 Media contribution
Press/Media: Expert Comment
-
Drug overdose prevention centres could prevent thousands of deaths
12/01/2024
1 Media contribution
Press/Media: Expert Comment