Nitric oxide-A novel therapeutic for cancer.

Jonathan Coulter, Helen McCarthy, J. Xiang, W. Roedl, E. Wagner, Tracy Robson, David Hirst

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Much research over the past two decades has focussed on understanding the complex interactions of nitric oxide (NO()) in both physiological and pathological processes. As with many other aspects of NO() biology, its precise role in tumour pathophysiology has been the cause of intense debate and we now know that it participates in numerous signalling pathways that are crucial to the malignant character of cancer. The available experimental evidence highlights contrasting pro- and anti-tumour effects of NO() expression, which appear to be reconciled by consideration of the concentrations involved. This review addresses the complexities of the role of NO() in cancer, whilst evaluating various experimental approaches to NO()-based cancer therapies, including both inhibition of nitric oxide synthases, and overexpression of NO() using donor drugs or nitric oxide synthase gene transfer. The evidence provided strongly supports a role for manipulation of tumour NO() either as a stand-alone therapy or in combination with conventional treatments to achieve a significant therapeutic gain.
Original languageEnglish
Pages (from-to)192-198
Number of pages7
JournalNitric oxide : biology and chemistry / official journal of the Nitric Oxide Society
Volume19(2)
Issue number2
Publication statusPublished - Sep 2008

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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