Nitric Oxide Adsorption and Delivery in Flexible MIL-88(Fe) Metal–Organic Frameworks

A.C. McKinlay, J. F. Eubank, S. Wuttke, B. Xiao, P. S. Wheatley, P. Bazin, J.-C. Lavalley, M. Daturi, A. Vimont, G. De Weireld, P. Horcajada, C. Serre, R. E. Morris

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159 Citations (Scopus)

Abstract

Adsorption and release of the biologically active nitric oxide (NO) was evaluated over a series of highly flexible iron(III) dicarboxylate MOFs of the MIL-88 structure type, bearing fumaric or terephthalic spacer functionalized or not by polar groups (NO2, 2OH). As evidenced by ex situ X-ray powder diffraction and in situ IR spectroscopy, it appears that if the contracted dried forms of MIL-88 do not expand their structures in the presence of NO, the combination of very narrow pores and trimers of iron polyhedra leads to the adsorption of significant amounts of NO either physisorbed (very narrow pores) and/or chemisorbed [iron(II) or iron(III) coordinatively unsaturated metal sites (CUS)]. The delivery of NO under vapor of water or in simulated body fluid does not exceed 20% range of the total adsorbed amount probably due to a partial release that occurs between the adsorption/desorption setup and the chemiluminescence release tests. Some of these solids nevertheless exhibit a significant release at the biological levels over a long period of time (>16 h) that make these biocompatible and biodegradable MOFs of interest for the controlled release of NO.
Original languageEnglish
Pages (from-to)1592-1599
JournalChemistry of Materials
Volume25
Issue number9
Early online date24 Mar 2013
DOIs
Publication statusPublished - 14 May 2013

ASJC Scopus subject areas

  • Materials Chemistry
  • Chemical Engineering(all)
  • Chemistry(all)

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