Nitrofuran antibacterials and the analysis of their residues in food

Gemma Regan, Christopher Elliott, Martin Danaher

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This article gives an overview on a class of antibacterial drugs called nitrofurans, which are prohibited from use in food-producing animals due to concerns regarding their undesirable toxicological properties. Nitrofuran drugs are rapidly metabolized in vivo to form highly stable protein-bound metabolites, which are used as marker residues when monitoring for their illegal presence in food. Strict legislation exists to ensure food safety and to protect consumers from these banned substances. This article explores the chemistry, mode of action and toxicity of nitrofuran drugs, as well as the occurrence of their residues in food and the most recent advances in analytical methodology for their detection.

Original languageEnglish
Title of host publicationEncyclopedia of food safety
EditorsGerald G. Moy, Peter Varelis, Geoffrey W. Smithers
PublisherElsevier Inc.
Pages461-469
Volume1
Edition2nd
ISBN (Electronic)9780128225202
ISBN (Print)9780128225219
DOIs
Publication statusPublished - 16 Oct 2023

Keywords

  • Banned antibacterial drugs
  • Bound metabolites
  • Furaltadone
  • Furazolidone
  • LC-MS/MS
  • Nifuraldezone
  • Nifuroxazide
  • Nifursol
  • Nitrofurans
  • Nitrofurantoin
  • Nitrofurazone
  • Nitrovin
  • Residue analysis

ASJC Scopus subject areas

  • General Engineering
  • General Agricultural and Biological Sciences

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