Abstract
This article gives an overview on a class of antibacterial drugs called nitrofurans, which are prohibited from use in food-producing animals due to concerns regarding their undesirable toxicological properties. Nitrofuran drugs are rapidly metabolized in vivo to form highly stable protein-bound metabolites, which are used as marker residues when monitoring for their illegal presence in food. Strict legislation exists to ensure food safety and to protect consumers from these banned substances. This article explores the chemistry, mode of action and toxicity of nitrofuran drugs, as well as the occurrence of their residues in food and the most recent advances in analytical methodology for their detection.
Original language | English |
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Title of host publication | Encyclopedia of food safety |
Editors | Gerald G. Moy, Peter Varelis, Geoffrey W. Smithers |
Publisher | Elsevier Inc. |
Pages | 461-469 |
Volume | 1 |
Edition | 2nd |
ISBN (Electronic) | 9780128225202 |
ISBN (Print) | 9780128225219 |
DOIs | |
Publication status | Published - 16 Oct 2023 |
Keywords
- Banned antibacterial drugs
- Bound metabolites
- Furaltadone
- Furazolidone
- LC-MS/MS
- Nifuraldezone
- Nifuroxazide
- Nifursol
- Nitrofurans
- Nitrofurantoin
- Nitrofurazone
- Nitrovin
- Residue analysis
ASJC Scopus subject areas
- General Engineering
- General Agricultural and Biological Sciences