No consistent evidence for association between mtDNA variants and Alzheimer disease

G Hudson, R Sims, D Harold, J Chapman, P Hollingworth, A Gerrish, G Russo, M Hamshere, V Moskvina, N Jones, C Thomas, A Stretton, P A Holmans, M C O'Donovan, M J Owen, J Williams, P F Chinnery, GERAD1 Consortium, Peter Passmore

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain.
Original languageEnglish
Pages (from-to)1038-42
Number of pages5
JournalNeurology
Volume78
Issue number14
DOIs
Publication statusPublished - 03 Apr 2012

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

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    Hudson, G., Sims, R., Harold, D., Chapman, J., Hollingworth, P., Gerrish, A., Russo, G., Hamshere, M., Moskvina, V., Jones, N., Thomas, C., Stretton, A., Holmans, P. A., O'Donovan, M. C., Owen, M. J., Williams, J., Chinnery, P. F., GERAD1 Consortium, & Passmore, P. (2012). No consistent evidence for association between mtDNA variants and Alzheimer disease. Neurology, 78(14), 1038-42. https://doi.org/10.1212/WNL.0b013e31824e8f1d