No consistent evidence for association between mtDNA variants and Alzheimer disease

G Hudson; R Sims; D Harold; J Chapman; P Hollingworth; A Gerrish; G Russo; M Hamshere; V Moskvina; N Jones; C Thomas; A Stretton; P A Holmans; M C O'Donovan; M J Owen; J Williams; P F Chinnery; GERAD1 Consortium; Peter Passmore

doi:10.1212/WNL.0b013e31824e8f1d

No consistent evidence for association between mtDNA variants and Alzheimer disease

G Hudson, R Sims, D Harold, J Chapman, P Hollingworth, A Gerrish, G Russo, M Hamshere, V Moskvina, N Jones, C Thomas, A Stretton, P A Holmans, M C O'Donovan, M J Owen, J Williams, P F Chinnery, GERAD1 Consortium, Peter Passmore

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain.

Original language	English
Pages (from-to)	1038-42
Number of pages	5
Journal	Neurology
Volume	78
Issue number	14
DOIs	https://doi.org/10.1212/WNL.0b013e31824e8f1d
Publication status	Published - 03 Apr 2012

ASJC Scopus subject areas

Clinical Neurology
Arts and Humanities (miscellaneous)

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Hudson, G., Sims, R., Harold, D., Chapman, J., Hollingworth, P., Gerrish, A., Russo, G., Hamshere, M., Moskvina, V., Jones, N., Thomas, C., Stretton, A., Holmans, P. A., O'Donovan, M. C., Owen, M. J., Williams, J., Chinnery, P. F., GERAD1 Consortium, & Passmore, P. (2012). No consistent evidence for association between mtDNA variants and Alzheimer disease. Neurology, 78(14), 1038-42. https://doi.org/10.1212/WNL.0b013e31824e8f1d

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author = "G Hudson and R Sims and D Harold and J Chapman and P Hollingworth and A Gerrish and G Russo and M Hamshere and V Moskvina and N Jones and C Thomas and A Stretton and Holmans, {P A} and O'Donovan, {M C} and Owen, {M J} and J Williams and Chinnery, {P F} and {GERAD1 Consortium} and Peter Passmore",

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Hudson, G, Sims, R, Harold, D, Chapman, J, Hollingworth, P, Gerrish, A, Russo, G, Hamshere, M, Moskvina, V, Jones, N, Thomas, C, Stretton, A, Holmans, PA, O'Donovan, MC, Owen, MJ, Williams, J, Chinnery, PF, GERAD1 Consortium & Passmore, P 2012, 'No consistent evidence for association between mtDNA variants and Alzheimer disease', Neurology, vol. 78, no. 14, pp. 1038-42. https://doi.org/10.1212/WNL.0b013e31824e8f1d

TY - JOUR

T1 - No consistent evidence for association between mtDNA variants and Alzheimer disease

AU - Hudson, G

AU - Sims, R

AU - Harold, D

AU - Chapman, J

AU - Hollingworth, P

AU - Gerrish, A

AU - Russo, G

AU - Hamshere, M

AU - Moskvina, V

AU - Jones, N

AU - Thomas, C

AU - Stretton, A

AU - Holmans, P A

AU - O'Donovan, M C

AU - Owen, M J

AU - Williams, J

AU - Chinnery, P F

AU - GERAD1 Consortium

AU - Passmore, Peter

PY - 2012/4/3

Y1 - 2012/4/3

N2 - Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain.

AB - Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain.

U2 - 10.1212/WNL.0b013e31824e8f1d

DO - 10.1212/WNL.0b013e31824e8f1d

M3 - Article

C2 - 22442439

VL - 78

SP - 1038

EP - 1042

JO - Neurology

JF - Neurology

IS - 14

ER -

No consistent evidence for association between mtDNA variants and Alzheimer disease

Abstract

ASJC Scopus subject areas

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