No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset

Elizabeth A Heron; Paul Cormican; Gary Donohoe; Francis A O'Neill; Kenneth S Kendler; Brien P Riley; Wellcome Trust Case Control Consortium 2; Michael Gill; Aiden P Corvin; Derek W Morris

doi:10.1016/j.schres.2014.01.038

No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset

Elizabeth A Heron, Paul Cormican, Gary Donohoe, Francis A O'Neill, Kenneth S Kendler, Brien P Riley, Wellcome Trust Case Control Consortium 2, Michael Gill, Aiden P Corvin, Derek W Morris

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Abstract

Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present in a homozygous and potentially recessive state. To detect rare risk variants for schizophrenia, we performed an ROH analysis in a homogeneous Irish genome wide association study (GWAS) dataset consisting of 1606 cases and 1794 controls. There was no genome-wide excess of ROH in cases compared to controls (p=0.7986). No consensus ROH at individual loci showed association with schizophrenia after genome-wide correction.

Original language	English
Pages (from-to)	79-82
Number of pages	4
Journal	Schizophrenia research
Volume	154
Issue number	1-3
Early online date	20 Feb 2014
DOIs	https://doi.org/10.1016/j.schres.2014.01.038
Publication status	Published - Apr 2014

Bibliographical note

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2014.01.038

http://www.sciencedirect.com/science/article/pii/S0920996414000619#

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Heron, E. A., Cormican, P., Donohoe, G., O'Neill, F. A., Kendler, K. S., Riley, B. P., Wellcome Trust Case Control Consortium 2, Gill, M., Corvin, A. P., & Morris, D. W. (2014). No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset. Schizophrenia research, 154(1-3), 79-82. https://doi.org/10.1016/j.schres.2014.01.038

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abstract = "Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present in a homozygous and potentially recessive state. To detect rare risk variants for schizophrenia, we performed an ROH analysis in a homogeneous Irish genome wide association study (GWAS) dataset consisting of 1606 cases and 1794 controls. There was no genome-wide excess of ROH in cases compared to controls (p=0.7986). No consensus ROH at individual loci showed association with schizophrenia after genome-wide correction.",

author = "Heron, {Elizabeth A} and Paul Cormican and Gary Donohoe and O'Neill, {Francis A} and Kendler, {Kenneth S} and Riley, {Brien P} and {Wellcome Trust Case Control Consortium 2} and Michael Gill and Corvin, {Aiden P} and Morris, {Derek W}",

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Heron, EA, Cormican, P, Donohoe, G, O'Neill, FA, Kendler, KS, Riley, BP, Wellcome Trust Case Control Consortium 2, Gill, M, Corvin, AP & Morris, DW 2014, 'No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset', Schizophrenia research, vol. 154, no. 1-3, pp. 79-82. https://doi.org/10.1016/j.schres.2014.01.038

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T1 - No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset

AU - Heron, Elizabeth A

AU - Cormican, Paul

AU - Donohoe, Gary

AU - O'Neill, Francis A

AU - Kendler, Kenneth S

AU - Riley, Brien P

AU - Wellcome Trust Case Control Consortium 2

AU - Gill, Michael

AU - Corvin, Aiden P

AU - Morris, Derek W

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AB - Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present in a homozygous and potentially recessive state. To detect rare risk variants for schizophrenia, we performed an ROH analysis in a homogeneous Irish genome wide association study (GWAS) dataset consisting of 1606 cases and 1794 controls. There was no genome-wide excess of ROH in cases compared to controls (p=0.7986). No consensus ROH at individual loci showed association with schizophrenia after genome-wide correction.

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DO - 10.1016/j.schres.2014.01.038

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VL - 154

SP - 79

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JO - Schizophrenia research

JF - Schizophrenia research

SN - 0920-9964

IS - 1-3

ER -

No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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