Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present in a homozygous and potentially recessive state. To detect rare risk variants for schizophrenia, we performed an ROH analysis in a homogeneous Irish genome wide association study (GWAS) dataset consisting of 1606 cases and 1794 controls. There was no genome-wide excess of ROH in cases compared to controls (p=0.7986). No consensus ROH at individual loci showed association with schizophrenia after genome-wide correction.
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Heron, E. A., Cormican, P., Donohoe, G., O'Neill, F. A., Kendler, K. S., Riley, B. P., Wellcome Trust Case Control Consortium 2, Gill, M., Corvin, A. P., & Morris, D. W. (2014). No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset. Schizophrenia research, 154(1-3), 79-82. https://doi.org/10.1016/j.schres.2014.01.038