No major schizophrenia locus detected on chromosome 1q in a large multicenter sample

Douglas F Levinson, Peter A Holmans, Claudine Laurent, Brien Riley, Ann E Pulver, Pablo V Gejman, Sibylle G Schwab, Nigel M Williams, Michael J Owen, Dieter B Wildenauer, Alan R Sanders, Gerald Nestadt, Bryan J Mowry, Brandon Wormley, Stephanie Bauché, Stephane Soubigou, Robert Ribble, Deborah A Nertney, Kung Yee Liang, Laura MartinolichWolfgang Maier, Nadine Norton, Hywel Williams, Margot Albus, Eric B Carpenter, Nicola DeMarchi, Kelly R Ewen-White, Dermot Walsh, Maurice Jay, Jean-François Deleuze, F Anthony O'Neill, George Papadimitriou, Ann Weilbaecher, Bernard Lerer, Michael C O'Donovan, Dimitris Dikeos, Jeremy M Silverman, Kenneth S Kendler, Jacques Mallet, Raymond R Crowe, Marilyn Walters

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.
Original languageEnglish
Pages (from-to)739-41
Number of pages3
JournalScience
Volume296
Issue number5568
DOIs
Publication statusPublished - 26 Apr 2002

Keywords

  • Africa
  • Alleles
  • Australia
  • Canada
  • Chromosomes, Human, Pair 1
  • Europe
  • Female
  • Genes, Recessive
  • Genetic Linkage
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Lod Score
  • Male
  • Microsatellite Repeats
  • Pedigree
  • Schizophrenia
  • United States

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  • Cite this

    Levinson, D. F., Holmans, P. A., Laurent, C., Riley, B., Pulver, A. E., Gejman, P. V., Schwab, S. G., Williams, N. M., Owen, M. J., Wildenauer, D. B., Sanders, A. R., Nestadt, G., Mowry, B. J., Wormley, B., Bauché, S., Soubigou, S., Ribble, R., Nertney, D. A., Liang, K. Y., ... Walters, M. (2002). No major schizophrenia locus detected on chromosome 1q in a large multicenter sample. Science, 296(5568), 739-41. https://doi.org/10.1126/science.1069914