No major schizophrenia locus detected on chromosome 1q in a large multicenter sample

Douglas F Levinson; Peter A Holmans; Claudine Laurent; Brien Riley; Ann E Pulver; Pablo V Gejman; Sibylle G Schwab; Nigel M Williams; Michael J Owen; Dieter B Wildenauer; Alan R Sanders; Gerald Nestadt; Bryan J Mowry; Brandon Wormley; Stephanie Bauché; Stephane Soubigou; Robert Ribble; Deborah A Nertney; Kung Yee Liang; Laura Martinolich; Wolfgang Maier; Nadine Norton; Hywel Williams; Margot Albus; Eric B Carpenter; Nicola DeMarchi; Kelly R Ewen-White; Dermot Walsh; Maurice Jay; Jean-François Deleuze; F Anthony O'Neill; George Papadimitriou; Ann Weilbaecher; Bernard Lerer; Michael C O'Donovan; Dimitris Dikeos; Jeremy M Silverman; Kenneth S Kendler; Jacques Mallet; Raymond R Crowe; Marilyn Walters

doi:10.1126/science.1069914

No major schizophrenia locus detected on chromosome 1q in a large multicenter sample

Douglas F Levinson, Peter A Holmans, Claudine Laurent, Brien Riley, Ann E Pulver, Pablo V Gejman, Sibylle G Schwab, Nigel M Williams, Michael J Owen, Dieter B Wildenauer, Alan R Sanders, Gerald Nestadt, Bryan J Mowry, Brandon Wormley, Stephanie Bauché, Stephane Soubigou, Robert Ribble, Deborah A Nertney, Kung Yee Liang, Laura MartinolichWolfgang Maier, Nadine Norton, Hywel Williams, Margot Albus, Eric B Carpenter, Nicola DeMarchi, Kelly R Ewen-White, Dermot Walsh, Maurice Jay, Jean-François Deleuze, F Anthony O'Neill, George Papadimitriou, Ann Weilbaecher, Bernard Lerer, Michael C O'Donovan, Dimitris Dikeos, Jeremy M Silverman, Kenneth S Kendler, Jacques Mallet, Raymond R Crowe, Marilyn Walters

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Abstract

Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.

Original language	English
Pages (from-to)	739-41
Number of pages	3
Journal	Science
Volume	296
Issue number	5568
DOIs	https://doi.org/10.1126/science.1069914
Publication status	Published - 26 Apr 2002

Keywords

Africa
Alleles
Australia
Canada
Chromosomes, Human, Pair 1
Europe
Female
Genes, Recessive
Genetic Linkage
Genetic Predisposition to Disease
Genotype
Humans
Lod Score
Male
Microsatellite Repeats
Pedigree
Schizophrenia
United States

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/science.1069914

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Levinson, D. F., Holmans, P. A., Laurent, C., Riley, B., Pulver, A. E., Gejman, P. V., Schwab, S. G., Williams, N. M., Owen, M. J., Wildenauer, D. B., Sanders, A. R., Nestadt, G., Mowry, B. J., Wormley, B., Bauché, S., Soubigou, S., Ribble, R., Nertney, D. A., Liang, K. Y., ... Walters, M. (2002). No major schizophrenia locus detected on chromosome 1q in a large multicenter sample. Science, 296(5568), 739-41. https://doi.org/10.1126/science.1069914

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title = "No major schizophrenia locus detected on chromosome 1q in a large multicenter sample",

abstract = "Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.",

keywords = "Africa, Alleles, Australia, Canada, Chromosomes, Human, Pair 1, Europe, Female, Genes, Recessive, Genetic Linkage, Genetic Predisposition to Disease, Genotype, Humans, Lod Score, Male, Microsatellite Repeats, Pedigree, Schizophrenia, United States",

author = "Levinson, {Douglas F} and Holmans, {Peter A} and Claudine Laurent and Brien Riley and Pulver, {Ann E} and Gejman, {Pablo V} and Schwab, {Sibylle G} and Williams, {Nigel M} and Owen, {Michael J} and Wildenauer, {Dieter B} and Sanders, {Alan R} and Gerald Nestadt and Mowry, {Bryan J} and Brandon Wormley and Stephanie Bauch{\'e} and Stephane Soubigou and Robert Ribble and Nertney, {Deborah A} and Liang, {Kung Yee} and Laura Martinolich and Wolfgang Maier and Nadine Norton and Hywel Williams and Margot Albus and Carpenter, {Eric B} and Nicola DeMarchi and Ewen-White, {Kelly R} and Dermot Walsh and Maurice Jay and Jean-Fran{\c c}ois Deleuze and O'Neill, {F Anthony} and George Papadimitriou and Ann Weilbaecher and Bernard Lerer and O'Donovan, {Michael C} and Dimitris Dikeos and Silverman, {Jeremy M} and Kendler, {Kenneth S} and Jacques Mallet and Crowe, {Raymond R} and Marilyn Walters",

year = "2002",

month = apr,

day = "26",

doi = "10.1126/science.1069914",

language = "English",

volume = "296",

pages = "739--41",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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Levinson, DF, Holmans, PA, Laurent, C, Riley, B, Pulver, AE, Gejman, PV, Schwab, SG, Williams, NM, Owen, MJ, Wildenauer, DB, Sanders, AR, Nestadt, G, Mowry, BJ, Wormley, B, Bauché, S, Soubigou, S, Ribble, R, Nertney, DA, Liang, KY, Martinolich, L, Maier, W, Norton, N, Williams, H, Albus, M, Carpenter, EB, DeMarchi, N, Ewen-White, KR, Walsh, D, Jay, M, Deleuze, J-F, O'Neill, FA, Papadimitriou, G, Weilbaecher, A, Lerer, B, O'Donovan, MC, Dikeos, D, Silverman, JM, Kendler, KS, Mallet, J, Crowe, RR & Walters, M 2002, 'No major schizophrenia locus detected on chromosome 1q in a large multicenter sample', Science, vol. 296, no. 5568, pp. 739-41. https://doi.org/10.1126/science.1069914

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AU - Levinson, Douglas F

AU - Holmans, Peter A

AU - Laurent, Claudine

AU - Riley, Brien

AU - Pulver, Ann E

AU - Gejman, Pablo V

AU - Schwab, Sibylle G

AU - Williams, Nigel M

AU - Owen, Michael J

AU - Wildenauer, Dieter B

AU - Sanders, Alan R

AU - Nestadt, Gerald

AU - Mowry, Bryan J

AU - Wormley, Brandon

AU - Bauché, Stephanie

AU - Soubigou, Stephane

AU - Ribble, Robert

AU - Nertney, Deborah A

AU - Liang, Kung Yee

AU - Martinolich, Laura

AU - Maier, Wolfgang

AU - Norton, Nadine

AU - Williams, Hywel

AU - Albus, Margot

AU - Carpenter, Eric B

AU - DeMarchi, Nicola

AU - Ewen-White, Kelly R

AU - Walsh, Dermot

AU - Jay, Maurice

AU - Deleuze, Jean-François

AU - O'Neill, F Anthony

AU - Papadimitriou, George

AU - Weilbaecher, Ann

AU - Lerer, Bernard

AU - O'Donovan, Michael C

AU - Dikeos, Dimitris

AU - Silverman, Jeremy M

AU - Kendler, Kenneth S

AU - Mallet, Jacques

AU - Crowe, Raymond R

AU - Walters, Marilyn

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N2 - Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.

AB - Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.

KW - Africa

KW - Alleles

KW - Australia

KW - Canada

KW - Chromosomes, Human, Pair 1

KW - Europe

KW - Female

KW - Genes, Recessive

KW - Genetic Linkage

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Lod Score

KW - Male

KW - Microsatellite Repeats

KW - Pedigree

KW - Schizophrenia

KW - United States

U2 - 10.1126/science.1069914

DO - 10.1126/science.1069914

M3 - Article

C2 - 11976456

SN - 0036-8075

VL - 296

SP - 739

EP - 741

JO - Science

JF - Science

IS - 5568

ER -

No major schizophrenia locus detected on chromosome 1q in a large multicenter sample

Abstract

Keywords

UN SDGs

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