Non-adherence in difficult asthma and advances in detection

John T Lindsay, Liam G Heaney

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)


Non-adherence to anti-inflammatory therapies is common in patients referred for specialist assessment at difficult-to-treat asthma services. In the difficult asthma setting, non-adherence to treatment is associated with poor baseline asthma control, increased frequency of exacerbations and asthma-related hospitalizations, as well as increased risk of death. Here, we present a review of the current literature surrounding the prevalence and risks of non-adherence in difficult asthma and we report on current methods of measuring treatment adherence and advances in the detection of non-adherence. We will also explore methods by which non-adherence in difficult asthma can be addressed.

Original languageEnglish
Pages (from-to)607-14
Number of pages8
JournalExpert review of respiratory medicine
Issue number6
Publication statusPublished - Dec 2013


  • Anti-Asthmatic Agents/therapeutic use
  • Asthma/drug therapy
  • Humans
  • Medication Adherence/statistics & numerical data
  • Patient Compliance/statistics & numerical data
  • Prevalence
  • Risk Factors
  • Self Report
  • Treatment Outcome


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