Non-enzymatic glycosylation

L Kennedy, T J Lyons

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Experience with the use of glycosylated haemoglobin throughout the 1980s has confirmed its uniqueness and usefulness as an objective index of long-term glycaemia in diabetes mellitus, and has enabled the definition of realistic and achievable targets for outpatient management. Measurement of glycosylated serum proteins yields information over a much shorter time-scale which may be particularly useful in diabetic pregnancy. The formation of advanced glycosylation end-products may provide a link between hyperglycaemia and chronic diabetic complications. Therapeutic inhibition or the promotion of alternative metabolic pathways, to yield inert glycosylated products, represents an innovative approach to the problem of preventing these complications.
Original languageEnglish
Pages (from-to)174-90
Number of pages17
JournalBritish Medical Bulletin
Volume45
Issue number1
Publication statusPublished - Jan 1989

Keywords

  • Blood Glucose
  • Blood Proteins
  • Diabetes Mellitus
  • Glycosylation
  • Hemoglobin A, Glycosylated
  • Humans
  • Time Factors

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