Non-enzymatic glycosylation of skin collagen in patients with type 1 (insulin-dependent) diabetes mellitus and limited joint mobility

T J Lyons, L Kennedy

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50 Citations (Scopus)

Abstract

Forearm skin biopsies were obtained from diabetic subjects with and without limited joint mobility, and from non-diabetic control subjects. Collagen purified from these samples was assayed for non-enzymatic glycosylation. The level in all diabetic patients was significantly greater than that in control subjects (p less than 0.001), but those diabetic patients with limited joint mobility had a level of collagen glycosylation similar to that in those with normal joints (15.3 +/- 1.3 and 16.5 +/- 1.3 nmol fructose/10 mg protein, respectively; mean +/- SEM). Glycosylation of collagen in the diabetic patients correlated with glycosylated haemoglobin measured at the time of skin biopsy (r = 0.60). These results do not support the hypothesis that non-enzymatic glycosylation of collagen, as reflected by the ketoamine link, plays an important role in the development of limited joint mobility in diabetes.
Original languageEnglish
Pages (from-to)2-5
Number of pages4
JournalDiabetologia
Volume28
Issue number1
Publication statusPublished - Jan 1985

Keywords

  • Adult
  • Collagen
  • Diabetes Mellitus, Type 1
  • Female
  • Hemoglobin A, Glycosylated
  • Humans
  • Joint Diseases
  • Male
  • Middle Aged
  • Skin

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