Non-steroidal anti-inflammatory drug use and brain tumour risk a case-control study within the Clinical Practice Research Datalink

F.J. Bannon, M.A. O'Rorke, L.J. Murray, C.M. Hughes, A.T. Gavin, S.J. Fleming, C.R. Cardwell

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose
The aetiology of primary brain tumours is largely unknown; the role of non-steroidal anti-inflammatory drugs (NSAIDs) or aspirin use and glioma risk has been inconclusive, but few population-based studies with reliable prescribing data have been conducted, and the association with meningioma risk has yet to be assessed. Methods: The UK Clinical Practice Research Datalink was used to assess the association between aspirin and non-aspirin NSAID use and primary brain tumour risk using a nested case-control study design. Conditional logistic regression analysis was performed on 5,052 brain tumour patients aged 16 years and over, diagnosed between 1987 and 2009 and 42,678 controls matched on year of birth, gender and general practice, adjusting for history of allergy and hormone replacement therapy use in the glioma and meningioma models, respectively.

Results
In conditional logistic regression analysis, excluding drug use in the year preceding the index date, there was no association with non-aspirin NSAID use (OR 0.96, 95 % CI 0.81-1.13) or glioma risk comparing the highest category of daily defined dose to non-users; however, non-aspirin NSAID use was positively associated with meningioma risk (OR 1.35, 95 % CI 1.06-1.71). No association was seen with high- or low-dose aspirin use irrespective of histology.

Conclusions
This large nested case-control study finds no association between aspirin or non-aspirin NSAID use and risk of glioma but a slight increased risk with non-aspirin NSAIDs and meningioma.
Original languageEnglish
Pages (from-to)2027-2034
Number of pages8
JournalCancer Causes & Control: an international journal of studies of cancer in human populations
Volume24
Issue number11
Early online date31 Aug 2013
DOIs
Publication statusPublished - Nov 2013

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