Non-thiazolidinedione antihyperglycemic agents. 1: Alpha-Heteroatom substituted-beta-phenylpropanoic acids.

D.R. Buckle; B.C.C. Cantello; M.A. Cawthorne; P.J. Coyle; D.K. Dean; A. Faller; David Haigh; R.M. Hindley; L. Jefcott; C.A. Lister; I.L. Pinto; H.K. Rami; D.G. Smith; S.A. Smith

Non-thiazolidinedione antihyperglycemic agents. 1: Alpha-Heteroatom substituted-beta-phenylpropanoic acids.

D.R. Buckle, B.C.C. Cantello, M.A. Cawthorne, P.J. Coyle, D.K. Dean, A. Faller, David Haigh, R.M. Hindley, L. Jefcott, C.A. Lister, I.L. Pinto, H.K. Rami, D.G. Smith, S.A. Smith

Research output: Contribution to journal › Article › peer-review

Abstract

A review with 22 refs. The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitizing antidiabetic agents can be replaced by a range of ?-heteroatom functionalized ?-phenylpropanoic acids. ?-Oxy-carboxylic acids show potent antidiabetic activity and one compd., the ?-ethoxyacid (SB 213068), is one of the most potent antihyperglycemic agents yet reported.

Original language	English
Pages (from-to)	2121-2126
Number of pages	6
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	6
Publication status	Published - 1996

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Buckle, D. R., Cantello, B. C. C., Cawthorne, M. A., Coyle, P. J., Dean, D. K., Faller, A., Haigh, D., Hindley, R. M., Jefcott, L., Lister, C. A., Pinto, I. L., Rami, H. K., Smith, D. G., & Smith, S. A. (1996). Non-thiazolidinedione antihyperglycemic agents. 1: Alpha-Heteroatom substituted-beta-phenylpropanoic acids. Bioorganic & Medicinal Chemistry Letters, 6, 2121-2126.

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title = "Non-thiazolidinedione antihyperglycemic agents. 1: Alpha-Heteroatom substituted-beta-phenylpropanoic acids.",

abstract = "A review with 22 refs. The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitizing antidiabetic agents can be replaced by a range of ?-heteroatom functionalized ?-phenylpropanoic acids. ?-Oxy-carboxylic acids show potent antidiabetic activity and one compd., the ?-ethoxyacid (SB 213068), is one of the most potent antihyperglycemic agents yet reported.",

author = "D.R. Buckle and B.C.C. Cantello and M.A. Cawthorne and P.J. Coyle and D.K. Dean and A. Faller and David Haigh and R.M. Hindley and L. Jefcott and C.A. Lister and I.L. Pinto and H.K. Rami and D.G. Smith and S.A. Smith",

year = "1996",

language = "English",

volume = "6",

pages = "2121--2126",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "1464-3405",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Non-thiazolidinedione antihyperglycemic agents. 1: Alpha-Heteroatom substituted-beta-phenylpropanoic acids.

AU - Buckle, D.R.

AU - Cantello, B.C.C.

AU - Cawthorne, M.A.

AU - Coyle, P.J.

AU - Dean, D.K.

AU - Faller, A.

AU - Haigh, David

AU - Hindley, R.M.

AU - Jefcott, L.

AU - Lister, C.A.

AU - Pinto, I.L.

AU - Rami, H.K.

AU - Smith, D.G.

AU - Smith, S.A.

PY - 1996

Y1 - 1996

N2 - A review with 22 refs. The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitizing antidiabetic agents can be replaced by a range of ?-heteroatom functionalized ?-phenylpropanoic acids. ?-Oxy-carboxylic acids show potent antidiabetic activity and one compd., the ?-ethoxyacid (SB 213068), is one of the most potent antihyperglycemic agents yet reported.

AB - A review with 22 refs. The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitizing antidiabetic agents can be replaced by a range of ?-heteroatom functionalized ?-phenylpropanoic acids. ?-Oxy-carboxylic acids show potent antidiabetic activity and one compd., the ?-ethoxyacid (SB 213068), is one of the most potent antihyperglycemic agents yet reported.

M3 - Article

SN - 1464-3405

VL - 6

SP - 2121

EP - 2126

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

ER -

Non-thiazolidinedione antihyperglycemic agents. 1: Alpha-Heteroatom substituted-beta-phenylpropanoic acids.

Abstract

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