Non-thiazolidinedione antihyperglycemic agents. 2: alpha-Carbon substituted-beta-phenylpropanoic acids.

D.R. Buckle, B.C.C. Cantello, M.A. Cawthorne, P.J. Coyle, D.K. Dean, A. Faller, David Haigh, R.M. Hindley, L.J. Jefcott, C.A. Lister, I.L. Pinto, H.K. Rami, D.G. Smith, S.A. Smith

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Buckle, D. R.; Cantello, B. C. C.; Cawthorne, M. A.; Coyle, P. J.; Dean, D. K.; Faller, A.; Haigh, D.; Hindley, R. M.; Lefcott, L. J.; et al. Dep. Medicinal Chem., Smithkline Beecham Pharmaceuticals, Surrey, UK. Bioorganic & Medicinal Chemistry Letters (1996), 6(17), 2127-2130. Publisher: Elsevier, CODEN: BMCLE8 ISSN: 0960-894X. Journal written in English. CAN 125:238227 AN 1996:573179 CAPLUS (Copyright (C) 2009 ACS on SciFinder (R)) Abstract The thiazolidine-2,4-dione ring of insulin-sensitizing antidiabetic agents can be replaced by ?-acyl-, ?-alkyl- and ?-(aralkyl)-carboxylic acids. The inclusion of an addnl. lipophilic moiety affords compds., equipotent to BRL 48482.
Original languageEnglish
Pages (from-to)2127-2130
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Publication statusPublished - 1996


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