Non-thiazolidinedione antihyperglycemic agents. 2: alpha-Carbon substituted-beta-phenylpropanoic acids.

D.R. Buckle, B.C.C. Cantello, M.A. Cawthorne, P.J. Coyle, D.K. Dean, A. Faller, David Haigh, R.M. Hindley, L.J. Jefcott, C.A. Lister, I.L. Pinto, H.K. Rami, D.G. Smith, S.A. Smith

Research output: Contribution to journalArticlepeer-review

Abstract

Buckle, D. R.; Cantello, B. C. C.; Cawthorne, M. A.; Coyle, P. J.; Dean, D. K.; Faller, A.; Haigh, D.; Hindley, R. M.; Lefcott, L. J.; et al. Dep. Medicinal Chem., Smithkline Beecham Pharmaceuticals, Surrey, UK. Bioorganic & Medicinal Chemistry Letters (1996), 6(17), 2127-2130. Publisher: Elsevier, CODEN: BMCLE8 ISSN: 0960-894X. Journal written in English. CAN 125:238227 AN 1996:573179 CAPLUS (Copyright (C) 2009 ACS on SciFinder (R)) Abstract The thiazolidine-2,4-dione ring of insulin-sensitizing antidiabetic agents can be replaced by ?-acyl-, ?-alkyl- and ?-(aralkyl)-carboxylic acids. The inclusion of an addnl. lipophilic moiety affords compds., equipotent to BRL 48482.
Original languageEnglish
Pages (from-to)2127-2130
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume6
Publication statusPublished - 1996

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