Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development

Kuljeet Singh Sandhu, Chengxi Shi, Mikael Sjölinder, Zhihu Zhao, Anita Göndör, Liang Liu, Vijay K. Tiwari, Sylvain Guibert, Lina Emilsson, Marta P. Imreh, Rolf Ohlsson

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76 Citations (Scopus)

Abstract

Recent observations highlight that the mammalian genome extensively communicates with itself via long-range chromatin interactions. The causal link between such chromatin cross-talk and epigenetic states is, however, poorly understood. We identify here a network of physically juxtaposed regions from the entire genome with the common denominator of being genomically imprinted. Moreover, CTCF-binding sites within the H19 imprinting control region (ICR) not only determine the physical proximity among imprinted domains, but also transvect allele-specific epigenetic states, identified by replication timing patterns, to interacting, nonallelic imprinted regions during germline development. We conclude that one locus can directly or indirectly pleiotropically influence epigenetic states of multiple regions on other chromosomes with which it interacts.
Original languageEnglish
Pages (from-to)2598-2603
Number of pages6
JournalGenes and Development
Volume23
Issue number22
DOIs
Publication statusPublished - 15 Nov 2009

Keywords

  • Epigenetics
  • H19 ICR
  • Imprinting
  • Replication timing
  • Transvection

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    Sandhu, K. S., Shi, C., Sjölinder, M., Zhao, Z., Göndör, A., Liu, L., Tiwari, V. K., Guibert, S., Emilsson, L., Imreh, M. P., & Ohlsson, R. (2009). Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development. Genes and Development, 23(22), 2598-2603. https://doi.org/10.1101/gad.552109