Notes on the Asymmetric Hydrogenation of Methyl Acetoacetate in Neoteric Solvents

T. Floris, P. Kluson, Mark Muldoon, H. Pelantova

Research output: Contribution to journalArticle

11 Citations (Scopus)


Asymmetric hydrogenation of methyl acetoacetate to methyl (R)-3-hydroxybutyrate by [(R)-RuCl(binap)( p-cymen)] Cl has been studied in methanol-ionic liquid and methanol-dense CO(2) solvent systems. The ionic pairs triethylhexylammonium and 1-methylimidazolium with bis(trifluoromethane sulfonyl) imide and hexafluorophosphates were used. The role of ionic pairs on the kinetic parameters and (enantio) selectivity has been demonstrated. Although the CO(2) expanded methanol system suffered from a reduction in both reaction rate and product selectivity, this changed in the presence of water. The high selectivity of the optimized methanol-CO(2)-water-halide system was designed as a consequence of observed additive effects.
Original languageEnglish
Pages (from-to)279-287
Number of pages9
JournalCatalysis Letters
Issue number3-4
Early online date11 Dec 2009
Publication statusPublished - Feb 2010

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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