Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections

Omar M. El-Halfawy; Marwa M. Naguib; Miguel A. Valvano

doi:10.1186/s13756-017-0279-8

Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections

Omar M. El-Halfawy, Marwa M. Naguib, Miguel A. Valvano

School of Medicine, Dentistry and Biomedical Sciences

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Abstract

Effective strategies to manage Burkholderia cepacia complex (Bcc) infections in cystic fibrosis (CF) patients are lacking. We tested combinations of clinically available antibiotics and show that moxifloxacin-ceftazidime could inhibit 16 Bcc clinical isolates at physiologically achievable concentrations. Adding low dose of colistin improved the efficacy of the combo, especially at conditions mimicking CF respiratory secretions.

Original language	English
Article number	120
Number of pages	5
Journal	Antimicrobial Resistance and Infection Control
Volume	6
Issue number	120
DOIs	https://doi.org/10.1186/s13756-017-0279-8
Publication status	Published - 25 Nov 2017

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10.1186/s13756-017-0279-8Licence: CC BY

Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections
Copyright 2017 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 986 KBLicence: CC BY

Cite this

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title = "Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections",

abstract = "Effective strategies to manage Burkholderia cepacia complex (Bcc) infections in cystic fibrosis (CF) patients are lacking. We tested combinations of clinically available antibiotics and show that moxifloxacin-ceftazidime could inhibit 16 Bcc clinical isolates at physiologically achievable concentrations. Adding low dose of colistin improved the efficacy of the combo, especially at conditions mimicking CF respiratory secretions.",

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AU - Naguib, Marwa M.

AU - Valvano, Miguel A.

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AB - Effective strategies to manage Burkholderia cepacia complex (Bcc) infections in cystic fibrosis (CF) patients are lacking. We tested combinations of clinically available antibiotics and show that moxifloxacin-ceftazidime could inhibit 16 Bcc clinical isolates at physiologically achievable concentrations. Adding low dose of colistin improved the efficacy of the combo, especially at conditions mimicking CF respiratory secretions.

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DO - 10.1186/s13756-017-0279-8

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JO - Antimicrobial Resistance and Infection Control

JF - Antimicrobial Resistance and Infection Control

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Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections

Abstract

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