Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections

Omar M. El-Halfawy, Marwa M. Naguib, Miguel A. Valvano

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1 Citation (Scopus)
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Abstract

Effective strategies to manage Burkholderia cepacia complex (Bcc) infections in cystic fibrosis (CF) patients are lacking. We tested combinations of clinically available antibiotics and show that moxifloxacin-ceftazidime could inhibit 16 Bcc clinical isolates at physiologically achievable concentrations. Adding low dose of colistin improved the efficacy of the combo, especially at conditions mimicking CF respiratory secretions.
Original languageEnglish
Article number120
Number of pages5
JournalAntimicrobial Resistance and Infection Control
Volume6
Issue number120
DOIs
Publication statusPublished - 25 Nov 2017

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