NOVEL COMPOUNDS AND USES

Luke A.J. O'Neill (Inventor), Rebecca Coll (Inventor), Matthew A Cooper (Inventor), Avril A B Robertson (Inventor), Kate Schroder (Inventor), Angus Murray Macleod (Inventor), David John Miller (Inventor)

Research output: Patent

Abstract

The present invention relates to compounds of formula (I): wherein Q is O or S; R1 is a cyclic group substituted with at least one group X, wherein R1 may optionally be further substituted; X is any group comprising a carbonyl group; and R2 is a cyclic group substituted at the α-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the dual action of NLRP3 inhibition and the stimulation of insulin secretion.
Original languageEnglish
Patent numberPCT/IB2017/053059
Filing date24/05/2017
Publication statusPublished - 29 Nov 2018

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Patents and inventions
Prodrugs
Salts
Insulin
Chemical analysis
Pharmaceutical Preparations

Cite this

O'Neill, L. A. J., Coll, R., Cooper, M. A., Robertson, A. A. B., Schroder, K., Macleod, A. M., & Miller, D. J. (2018). NOVEL COMPOUNDS AND USES. (Patent No. PCT/IB2017/053059).
O'Neill, Luke A.J. (Inventor) ; Coll, Rebecca (Inventor) ; Cooper, Matthew A (Inventor) ; Robertson, Avril A B (Inventor) ; Schroder, Kate (Inventor) ; Macleod, Angus Murray (Inventor) ; Miller, David John (Inventor). / NOVEL COMPOUNDS AND USES. Patent No.: PCT/IB2017/053059. May 24, 2017.
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abstract = "The present invention relates to compounds of formula (I): wherein Q is O or S; R1 is a cyclic group substituted with at least one group X, wherein R1 may optionally be further substituted; X is any group comprising a carbonyl group; and R2 is a cyclic group substituted at the α-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the dual action of NLRP3 inhibition and the stimulation of insulin secretion.",
author = "O'Neill, {Luke A.J.} and Rebecca Coll and Cooper, {Matthew A} and Robertson, {Avril A B} and Kate Schroder and Macleod, {Angus Murray} and Miller, {David John}",
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O'Neill, LAJ, Coll, R, Cooper, MA, Robertson, AAB, Schroder, K, Macleod, AM & Miller, DJ May. 24 2017, NOVEL COMPOUNDS AND USES, Patent No. PCT/IB2017/053059.

NOVEL COMPOUNDS AND USES. / O'Neill, Luke A.J. (Inventor); Coll, Rebecca (Inventor); Cooper, Matthew A (Inventor); Robertson, Avril A B (Inventor); Schroder, Kate (Inventor); Macleod, Angus Murray (Inventor); Miller, David John (Inventor).

Patent No.: PCT/IB2017/053059. May 24, 2017.

Research output: Patent

TY - PAT

T1 - NOVEL COMPOUNDS AND USES

AU - O'Neill, Luke A.J.

AU - Coll, Rebecca

AU - Cooper, Matthew A

AU - Robertson, Avril A B

AU - Schroder, Kate

AU - Macleod, Angus Murray

AU - Miller, David John

PY - 2018/11/29

Y1 - 2018/11/29

N2 - The present invention relates to compounds of formula (I): wherein Q is O or S; R1 is a cyclic group substituted with at least one group X, wherein R1 may optionally be further substituted; X is any group comprising a carbonyl group; and R2 is a cyclic group substituted at the α-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the dual action of NLRP3 inhibition and the stimulation of insulin secretion.

AB - The present invention relates to compounds of formula (I): wherein Q is O or S; R1 is a cyclic group substituted with at least one group X, wherein R1 may optionally be further substituted; X is any group comprising a carbonyl group; and R2 is a cyclic group substituted at the α-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the dual action of NLRP3 inhibition and the stimulation of insulin secretion.

M3 - Patent

M1 - PCT/IB2017/053059

Y2 - 2017/05/24

ER -

O'Neill LAJ, Coll R, Cooper MA, Robertson AAB, Schroder K, Macleod AM et al, inventors. NOVEL COMPOUNDS AND USES. PCT/IB2017/053059. 2018 Nov 29.