Abstract
Abstract: The focus on novel systems for transdermal delivery of therapeutic agents has increased
considerably over recent years, as this administration route comes with many advantages. Polymeric
microarray patches (MAPs) are minimally invasive devices that enable systemic delivery of a
wide range of drugs by overcoming the outer skin barrier. Conventionally, MAPs fabricated by
micromoulding have a low needle density. In this study, the performance of hydrogel-forming
MAPs cast using novel industrially manufactured micromoulds with a high needle density
(600 needles/0.75 cm2
) was compared to that of MAPs obtained using conventional moulds with
a lower density (196 needles/0.89 cm2
). Surrounding holders for micromoulds were designed for
time-efficient fabrication of MAPs. The influence of needle densities on mechanical strength, insertion
efficiency and in vitro permeation of ibuprofen sodium (IBU) was analysed. Insertion of both MAPs
into an artificial skin model and neonatal porcine skin was comparable. No significant difference
was observed in permeation studies of IBU (p > 0.05), with a delivery of 8.7 ± 1.7 mg for low-density
and 9.5 ± 0.1 mg for high-density MAPs within 24 h. This highlights the potential of these novel
micromoulds for manufacturing polymeric MAPs with a higher needle density for future applications.
Original language | English |
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Article number | 554 |
Journal | Micromachines |
Volume | 11 |
DOIs | |
Publication status | Published - 30 May 2020 |
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Dive into the research topics of 'Novel Design Approaches in the Fabrication of Polymeric Microarray Patches via Micromoulding'. Together they form a unique fingerprint.Student theses
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Lymph-targeted intradermal delivery of antiretroviral agents via dissolving polymeric microarray patches
Ramöller, I. K. (Author), Donnelly, R. (Supervisor) & Larraneta Landa, E. (Supervisor), Dec 2021Student thesis: Doctoral Thesis › Doctor of Philosophy