Novel nanoparticle vaccines for listeriosis

Ricardo Calderon-Gonzalez, Marco Marradi, Isabel Garcia, Nikolai Petrovsky, Carmen Alvarez-Dominguez

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

In recent years, nanomedicine has transformed many areas of traditional medicine, and enabled fresh insights into the prevention of previously difficult to treat diseases. An example of the transformative power of nanomedicine is a recent nano-vaccine against listeriosis, a serious bacterial infection affecting not only pregnant women and their neonates, but also immune-compromised patients with neoplastic or chronic autoimmune diseases. There is a major unmet need for an effective and safe vaccine against listeriosis, with the challenge that an effective vaccine needs to generate protective T cell immunity, a hitherto difficult to achieve objective. Now utilizing a gold nanoparticle antigen delivery approach together with a novel polysaccharide nanoparticulate adjuvant, an effective T-cell vaccine has been developed that provides robust protection in animal models of listeriosis, raising the hope that one day this nanovaccine technology may protect immune-compromised humans against this serious opportunistic infection.
Original languageEnglish
Pages (from-to)2501-2503
Number of pages3
JournalHuman Vaccines & Immunotherapeutics
Volume11
Issue number10
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Listeria
  • LLO peptide
  • Nanoparticles
  • Adjuvant
  • Vaccine

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