Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD-dependent enzymes

Marie Migaud, Nathalie Batoux, F. Paradisis, P.C. Engel

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD+) have been synthesised from -ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable. They have been evaluated as inhibitors of adenosine diphosphate ribosyl cyclase, glutamate dehydrogenase and Sir2 acyltransferase activities. Enzyme specificity and a high level of inhibition was observed for the dehydrogenase.
Original languageEnglish
Pages (from-to)6609-6617
Number of pages9
JournalTetrahedron
Volume60(31)
Issue number31
DOIs
Publication statusPublished - 26 Jul 2004

Fingerprint

NAD
Acyltransferases
Thiophenes
Glutamate Dehydrogenase
Niacinamide
Enzymes
Adenosine Diphosphate
Oxidoreductases
ribonolactone

Cite this

Migaud, Marie ; Batoux, Nathalie ; Paradisis, F. ; Engel, P.C. / Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD-dependent enzymes. In: Tetrahedron. 2004 ; Vol. 60(31), No. 31. pp. 6609-6617.
@article{c75d91962c834280ba5af0056a1f84a2,
title = "Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD-dependent enzymes",
abstract = "Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD+) have been synthesised from -ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable. They have been evaluated as inhibitors of adenosine diphosphate ribosyl cyclase, glutamate dehydrogenase and Sir2 acyltransferase activities. Enzyme specificity and a high level of inhibition was observed for the dehydrogenase.",
author = "Marie Migaud and Nathalie Batoux and F. Paradisis and P.C. Engel",
year = "2004",
month = "7",
day = "26",
doi = "10.1016/j.tet.2004.05.091",
language = "English",
volume = "60(31)",
pages = "6609--6617",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "31",

}

Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD-dependent enzymes. / Migaud, Marie; Batoux, Nathalie; Paradisis, F.; Engel, P.C.

In: Tetrahedron, Vol. 60(31), No. 31, 26.07.2004, p. 6609-6617.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD-dependent enzymes

AU - Migaud, Marie

AU - Batoux, Nathalie

AU - Paradisis, F.

AU - Engel, P.C.

PY - 2004/7/26

Y1 - 2004/7/26

N2 - Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD+) have been synthesised from -ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable. They have been evaluated as inhibitors of adenosine diphosphate ribosyl cyclase, glutamate dehydrogenase and Sir2 acyltransferase activities. Enzyme specificity and a high level of inhibition was observed for the dehydrogenase.

AB - Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD+) have been synthesised from -ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable. They have been evaluated as inhibitors of adenosine diphosphate ribosyl cyclase, glutamate dehydrogenase and Sir2 acyltransferase activities. Enzyme specificity and a high level of inhibition was observed for the dehydrogenase.

UR - http://www.scopus.com/inward/record.url?scp=4143139046&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2004.05.091

DO - 10.1016/j.tet.2004.05.091

M3 - Article

VL - 60(31)

SP - 6609

EP - 6617

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 31

ER -