Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD-dependent enzymes

Marie Migaud, Nathalie Batoux, F. Paradisis, P.C. Engel

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD+) have been synthesised from -ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable. They have been evaluated as inhibitors of adenosine diphosphate ribosyl cyclase, glutamate dehydrogenase and Sir2 acyltransferase activities. Enzyme specificity and a high level of inhibition was observed for the dehydrogenase.
Original languageEnglish
Pages (from-to)6609-6617
Number of pages9
JournalTetrahedron
Volume60(31)
Issue number31
DOIs
Publication statusPublished - 26 Jul 2004

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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