Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD-dependent enzymes

Marie Migaud; Nathalie Batoux; F. Paradisis; P.C. Engel

doi:10.1016/j.tet.2004.05.091

Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD-dependent enzymes

Marie Migaud, Nathalie Batoux, F. Paradisis, P.C. Engel

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD+) have been synthesised from -ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable. They have been evaluated as inhibitors of adenosine diphosphate ribosyl cyclase, glutamate dehydrogenase and Sir2 acyltransferase activities. Enzyme specificity and a high level of inhibition was observed for the dehydrogenase.

Original language	English
Pages (from-to)	6609-6617
Number of pages	9
Journal	Tetrahedron
Volume	60(31)
Issue number	31
DOIs	https://doi.org/10.1016/j.tet.2004.05.091
Publication status	Published - 26 Jul 2004

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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10.1016/j.tet.2004.05.091

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title = "Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD-dependent enzymes",

abstract = "Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD+) have been synthesised from -ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable. They have been evaluated as inhibitors of adenosine diphosphate ribosyl cyclase, glutamate dehydrogenase and Sir2 acyltransferase activities. Enzyme specificity and a high level of inhibition was observed for the dehydrogenase.",

author = "Marie Migaud and Nathalie Batoux and F. Paradisis and P.C. Engel",

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T1 - Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD-dependent enzymes

AU - Migaud, Marie

AU - Batoux, Nathalie

AU - Paradisis, F.

AU - Engel, P.C.

PY - 2004/7/26

Y1 - 2004/7/26

N2 - Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD+) have been synthesised from -ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable. They have been evaluated as inhibitors of adenosine diphosphate ribosyl cyclase, glutamate dehydrogenase and Sir2 acyltransferase activities. Enzyme specificity and a high level of inhibition was observed for the dehydrogenase.

AB - Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD+) have been synthesised from -ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable. They have been evaluated as inhibitors of adenosine diphosphate ribosyl cyclase, glutamate dehydrogenase and Sir2 acyltransferase activities. Enzyme specificity and a high level of inhibition was observed for the dehydrogenase.

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U2 - 10.1016/j.tet.2004.05.091

DO - 10.1016/j.tet.2004.05.091

M3 - Article

SN - 0040-4020

VL - 60(31)

SP - 6609

EP - 6617

JO - Tetrahedron

JF - Tetrahedron

IS - 31

ER -

Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD-dependent enzymes

Abstract

ASJC Scopus subject areas

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