Obesity and Breast Cancer

Renée T. Fortner, Verena Katzke, Tilman Kühn, R. Kaaks

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The relationship between adiposity and breast cancer risk and prognosis is complex, with associations that differ depending on when body size is assessed (e.g., pre- vs. postmenopausal obesity) and when breast cancer is diagnosed (i.e., pre- vs. postmenopausal disease). Further, the impact of obesity on risk differs by tumor hormone receptor status (e.g., estrogen (ER) and progesterone (PR) receptor) and, among postmenopausal women, use of exogenous hormones (i.e., hormone replacement therapy (HRT)). In the context of these complexities, this review focuses on associations between childhood and adolescent adiposity, general adiposity, weight changes (i.e., loss and gain), abdominal adiposity, and breast cancer risk and survival. Finally, we discuss potential mechanisms linking adiposity to breast cancer.
Original languageUndefined/Unknown
Pages (from-to)43-65
Number of pages23
JournalRecent Results in Cancer Research
Volume208
DOIs
Publication statusPublished - 02 Dec 2016

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