Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing

Sophia Pathai, Paul G Shiels, Helen A Weiss, Clare E Gilbert, Tunde Peto, Linda-Gail Bekker, Robin Wood, Tien Y Wong, Stephen D Lawn

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

HIV-infected individuals have an increased risk of age-related morbidity despite antiretroviral treatment (ART). Several anatomic and functional ophthalmological parameters are associated with increasing chronological age. These may, therefore, potentially serve as biomarkers of ageing. We investigated associations between ocular parameters (lens density, retinal vessel calibre, corneal endothelium and retinal nerve fibre layer thickness) and two 'cellular' biomarkers of ageing (leukocyte telomere length and CDKN2A expression) and with frailty in a cross-sectional study of 216 HIV-infected individuals. All ocular parameters, telomere length and frailty were associated with chronological age, whereas CDKN2A expression was not. Retinal venular calibre and lens density were associated with shorter telomere length (p-trend=0.04, and 0.08, respectively), whereas CDKN2A expression and frailty status were not associated with ocular parameters. Longitudinal studies are warranted to assess the integration of retinal vascular calibre and lens density with systemic markers to develop an overall index of biological ageing in HIV infection.

Original languageEnglish
Pages (from-to)400-6
Number of pages7
JournalMechanisms of Ageing and Development
Volume134
Issue number9
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Adult
  • Aging
  • Anthropometry
  • Anti-Retroviral Agents
  • Biomarkers
  • Blood Pressure
  • Cornea
  • Cross-Sectional Studies
  • Cyclin-Dependent Kinase Inhibitor p16
  • Female
  • HIV Infections
  • Humans
  • Lens, Crystalline
  • Male
  • Middle Aged
  • Retina
  • Retinal Vessels
  • South Africa
  • Telomere
  • Vision, Ocular
  • Journal Article
  • Research Support, Non-U.S. Gov't

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