Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry

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6 Citations (Scopus)

Abstract

Photoresponsive oligonucleotides (ONs) incorporating isoxazole-linked azobenzene (AB) moieties were prepared by resin-supported nitrile oxide-alkyne cycloaddition (NOAC) chemistry. The thermal and photochromic properties of the modified ONs were significantly influenced by the extent of pi-conjugation between the isoxazole and the AB modules.
Original languageEnglish
Article number DOI: 10.1039/c2ra22815g
Pages (from-to)1652-1655
Number of pages4
JournalRSC Advances
Volume3
Issue number6
DOIs
Publication statusPublished - 12 Feb 2013

Keywords

  • COVALENT MODIFICATION
  • FUNCTIONALIZATION
  • AZOBENZENE
  • DNA HYBRIDIZATION

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