Photoresponsive oligonucleotides (ONs) incorporating isoxazole-linked azobenzene (AB) moieties were prepared by resin-supported nitrile oxide-alkyne cycloaddition (NOAC) chemistry. The thermal and photochromic properties of the modified ONs were significantly influenced by the extent of pi-conjugation between the isoxazole and the AB modules.
- COVALENT MODIFICATION
- DNA HYBRIDIZATION
Vyle, J. (2013). Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry. RSC Advances, 3 (6), 1652-1655. [ DOI: 10.1039/c2ra22815g ]. https://doi.org/10.1039/c2ra22815g