Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry

Joseph Vyle

doi:10.1039/c2ra22815g

Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry

Joseph Vyle

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Photoresponsive oligonucleotides (ONs) incorporating isoxazole-linked azobenzene (AB) moieties were prepared by resin-supported nitrile oxide-alkyne cycloaddition (NOAC) chemistry. The thermal and photochromic properties of the modified ONs were significantly influenced by the extent of pi-conjugation between the isoxazole and the AB modules.

Original language	English
Article number	DOI: 10.1039/c2ra22815g
Pages (from-to)	1652-1655
Number of pages	4
Journal	RSC Advances
Volume	3
Issue number	6
DOIs	https://doi.org/10.1039/c2ra22815g
Publication status	Published - 12 Feb 2013

Keywords

COVALENT MODIFICATION
FUNCTIONALIZATION
AZOBENZENE
DNA HYBRIDIZATION

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10.1039/c2ra22815g

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abstract = "Photoresponsive oligonucleotides (ONs) incorporating isoxazole-linked azobenzene (AB) moieties were prepared by resin-supported nitrile oxide-alkyne cycloaddition (NOAC) chemistry. The thermal and photochromic properties of the modified ONs were significantly influenced by the extent of pi-conjugation between the isoxazole and the AB modules.",

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KW - COVALENT MODIFICATION

KW - FUNCTIONALIZATION

KW - AZOBENZENE

KW - DNA HYBRIDIZATION

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DO - 10.1039/c2ra22815g

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Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry

Abstract

Keywords

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